Abstract: by peripheral Sezary cells from a patient with Sézary syndrome. They were not reactme with normal peripheral mononuclear cells but with activated T cells and epidermal keratinocytes. It provided the direct laboratory evidence to show that cutaneous T-cell lymphoma (CTCL) cell; shared common surface antigen with activated helper T cells (T_H) and keratinocytes and also suggested that CTCL cells eventually become malignancy under the influence and interation of activated T_H and keratoincytes.