Abstract: Three cutaneous T-cell lymphoma (CTCL) patients are reported in this paper. Accoording to examinations with anti-Leu1, Leu3a, Leu4, and HLA-DR monoclonal antibodies, two cases were diagnosed as epidermotropic CTCL and one case was diagnosed as non-epidermotropic CTCL. The diagnosis and treatment of CTCL were discussed.