中华皮肤科杂志 ›› 2013, Vol. 46 ›› Issue (4): 270-272.

• 论著 • 上一篇    下一篇

单一损害的间质性蕈样肉芽肿一例

陈思远1,杨珍1,夏颖2,钱悦3,朱里4,吴艳5,刘志香4,涂亚庭4,4,王椿森6,黄长征7   

  1. 1. 武汉市华中科技大学同济医学院附属协和医院皮肤科
    2. 武汉华中科技大学同济医学院附属协和医院
    3. 武汉协和医院皮肤科
    4. 武汉华中科技大学同济医学院附属协和医院皮肤科
    5. 武汉市协和医院皮肤科
    6. 华中科技大学同济医学院附属协和医院
    7. 华中科技大学同济医学院附属协和医院皮肤科
  • 收稿日期:2012-08-27 修回日期:2013-02-04 出版日期:2013-04-15 发布日期:2013-04-01
  • 通讯作者: 黄长征 E-mail:hcz0501@126.com
  • 基金资助:
    国家自然科学基金

Unilesional interstitial mycosis fungoides: a case report

  • Received:2012-08-27 Revised:2013-02-04 Online:2013-04-15 Published:2013-04-01
  • Contact: HUANG Chang-Zheng E-mail:hcz0501@126.com
  • Supported by:
    National Natural Science Foundation of China

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摘要： 患者男，42岁，右侧胸背部无明显自觉症状的浸润性淡红斑半月余，皮疹缓慢扩大。皮肤科检查：右侧胸背部腋后线肩胛骨下方一5 cm × 7 cm边界模糊的浸润性淡红斑。皮损组织病理检查：真皮浅层及中下部胶原纤维束间较多单一核细胞浸润，部分细胞侵入表皮形成Pautrier微脓肿，部分细胞有轻度异形。免疫组化染色：单一核细胞CD3、CD5、CD8、CD45Ro、细胞毒颗粒相关蛋白（TIA-1）均阳性（+），CD4散在阳性（+），CD7、CD20、CD30、CD56、CD68、CD79α、粒酶B均阴性，Ki67阳性 > 20%，T细胞受体重排检测阴性。诊断：单一损害的间质性蕈样肉芽肿。 【关键词】 真菌病，蕈样； 病例报告［文献类型］

关键词: 蕈样肉芽肿, 病例报告[文献类型]

Abstract: CHEN Si-yuan, YANG Zhen, XIA Ying, QIAN Yue, ZHU Li, WU Yan, LIU Zhi-xiang, TU Ya-ting, WANG Chun-sen, HUANG Chang-zheng. Department of Dermatology, Union Hospital, Tongji Medical College，Huazhong University of Science and Technology, Wuhan 430022，China Corresponding author: HUANG Chang-zheng, Email: hcz0501@126.com 【Abstract】 A 42-year-old man presented with a slowly spreading, asymptomatic, infiltrated erythematous patch in the right side of the chest and back for more than half a month. Dermatologic examination revealed a poorly marginated, pink infiltrated patch sized 5 cm × 7 cm in the right subscapular region of the back and chest. Histopathologically, there was an infiltrate of numerous mononuclear cells in the superficial dermis as well as between collagen fibers in the middle and deep dermis, with epidermotropism of some cells and formation of Pautrier's microabscesses. Mild atypia was observed in some infiltrating mononuclear cells. Immunohistochemistry showed that the mononuclear cells were positive for CD3, CD4 （scattered）, CD5, CD8, CD45Ro, the cytotoxic-granule-associated protein TIA-1, but negative for CD7, CD20, CD30, CD56, CD68, CD79α, and granzyme B, with the percentage of Ki-67-positive cells higher than 20%. T cell receptor （TCR） rearrangement was negative. The final diagnosis was unilesional interstitial mycosis fungoides. 【Key words】 Mycosis fungoides; Case reports ［Publication type］

Key words: Mycosis Fungoides