中华皮肤科杂志 ›› 1995, Vol. 28 ›› Issue (4): 210-212.

• 论著 • 上一篇    下一篇

聚合酶链反应检测带状疱疹皮损治愈前后水痘-带状疱疹病毒DNA

朱文元1, 徐美萍2   

  1. 1. 南京医科大学第一附属医院皮肤科 210029;
    2. 南京医科大学第二附属医院皮肤科
  • 收稿日期:1994-10-17 修回日期:1994-12-26 出版日期:1995-08-15 发布日期:1995-08-15
  • 基金资助:
    非教育系统回国留学人员科研资助

Detection of Varicella-Zoster Virus DNA within Healed Skin Lesions of Herpes Zoster

Zhu Wenyuan1, Xu Meiping2   

  1. The First Affiliated Hospital, Nanjing Medical University, Nanjing 210029
  • Received:1994-10-17 Revised:1994-12-26 Online:1995-08-15 Published:1995-08-15

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摘要： 我们用聚合酶链反应检测16例带状疱疹水疱和治愈后皮肤中水痘-带状疱疹病毒(VZV)。在16例所有水疱损害中均可检测到385bp的VZV DNA片断。6例痊愈2个月内活检组织中2例(33.3%)检测到VZV DNA。10例超过2个月的临床治愈皮损内均未检测到VZV DNA。VZV可在带状疱疹治愈皮损中短期存在。

关键词: 带状疱疹, 水痘-带状疱疹病毒

Abstract: We detected varicella-zoster virus (VZV) DNA sequences in bullous lesions and skin biopsies obtained from healed skin lesions in 16 patients with herpes zoster using polymerase chain reaction. A 385 bp VZV DNA fragment was found in all the bullous lesions and in two of six biopsies from the skin lesions healed within two months. No VZV DNA was found in the skin lesions two months after healing in 10 cases of herpes zoster. VZV DNA may be detected at the sites of resolved herpes zoster lesions within short duration.

Key words: Herpes zoster, Varicella-zoster virus