中华皮肤科杂志 ›› 1995, Vol. 28 ›› Issue (4): 207-209.

• 论著 •    下一篇

系统性红斑狼疮患者纤溶功能测定

姜学义, 峰下哲, 韩春雷, 杨学莉, 汪整辉, 寇丽筠, 王黎曼, 杨杰   

  1. 北京医科大学第三医院 100083
  • 收稿日期:1994-09-02 修回日期:1994-12-17 出版日期:1995-08-15 发布日期:1995-08-15
  • 基金资助:
    国家自然科学基金

The Assay of Fibrinolytic Function in the Patients with SLE and its Significance

Jiang Xueyi, Feng Xiazhe, Han Chunlei   

  1. The Third Hospital, Beijing Medical University, Beijing 100083
  • Received:1994-09-02 Revised:1994-12-17 Online:1995-08-15 Published:1995-08-15

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摘要： 采用发色底物法和免疫扩散法测定98例SLE患者的纤溶功能,其中19例做了连续性观察。结果显示:纤溶功能低下与病情的严重性和难治性有关,所有患者纤溶酶原激活抑制物(PAI)活性均明显高于正常,有肾炎者组织型纤溶酶原激活物(t-PA)活性与PAI活性比值显著降低,难治性狼疮肾炎不但PAI活性明显增高,而且t-PA活性明显降低,故t-PA与PAI活性比值更低,提示与难治性相关。病情缓解者虽然PAI活性仍明显高于正常,但t-PA活性也增高,故t-PA与PAI活性比值基本正常。

关键词: 红斑狼疮, 全身性, 纤维蛋白溶酶, 血纤维蛋白溶酶原激活剂, 组织类型, 抑制物

Abstract: The fibrinolytic function of 98 patients with SLE were determined by spectrophotometric assay and immunodiffusion, 19 patients were observed before treatment, 1 month after treatment and 3 months after the disappearance of clinical symptoms. The results showed that the low level of fibrinolytic function correlated to the severity and the refractoriness of the disease, the activity of plasminogen activator inhibitor (PAI) was significantly increased in all patients. The activity ratio of tissue-type plasminogen activator (t-PA):PAI was significantly lower than normal level in the patients with lupus nephritis, not only the activity of PAI increased significantly, but also the activity of t-PA was significantly decreased, so the activity ratio of t-PA:PAI became much lower, the result suggested that it was related to the refractoriness of the disease. In patients in clinical remission, although the activity of PAI was still higher than normal level, the activity of t-PA was also significantly increased, therefore, the activity ratio of t-PA:PAI was nearly normal.

Key words: Lupus erythematosus, systemic, Fibrinolysin, Plasminogen activator, tissuetype, Plasminogen activator inhibitor