中华皮肤科杂志 ›› 1995, Vol. 28 ›› Issue (5): 301-303.

• 论著 • 上一篇    下一篇

国产氟嗪酸抗麻风的临床和实验研究

吴钦强1, 李文忠1, 沈建平1, 叶干运1, 黄文标2, 刘风梧2, 张世保2, 何兰奉2   

  1. 1. 中国医学科学院、中国协和医科大学皮肤病研究所, 南京 210042;
    2. 云南省皮肤病研究所
  • 收稿日期:1994-11-11 修回日期:1995-03-11 出版日期:1995-10-15 发布日期:1995-10-15

Activity of Home-made Ofloxacin Against M.leprae in Mice and its Clinical Trial in Multibacillary Leprosy

Wu Tieqiang1, Li Wenzhong1, Shen Jianping 1   

  1. Institute of Dermatology, Chinese Academy of Medical Sciences, Peking Union Medical College, Nanjing 210042
  • Received:1994-11-11 Revised:1995-03-11 Online:1995-10-15 Published:1995-10-15

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摘要： 于免疫正常小鼠双后足垫感染1.0×104条麻风菌70天后,给予国产氟障酸150mg/kg每周5次管饲,共63天.同时设无药组、进口氟嗪酸和利福平治疗组作对照.结果示无药组小鼠麻风菌繁殖良好,国产氟嗪酸治疗组小鼠与进口氟嗪酸和利福平治疗组的一样,直到感染12个月,所有小鼠足垫均未检出抗酸菌.11例新发未治BL/LL病人和 2例氨苯砜长期单疗复发的BL/LL病人,以氟嗪酸400mg每日1次,每周6次,监服12周.结果示皮损有明显进步;细菌形态指数疗前平均为11.89%,治疗2周时降至2.59%,治疗4周时降至0%;细菌指数疗前平均为4.28,疗程结束时降至3.90.疗程中4例发生Ⅱ型麻风反应,全部患者对药物耐受良好.结果提示国产氟嗪酸抗麻风菌作用与国外的报告相似.该药可作为麻风联合化疗药物之一.

关键词: 麻风, 氟嗪酸

Abstract: Seventy days after inoculation of 1.0 × 104 M.leprae to the foot-pads,the mice were treated with home-made ofloxacin 150mg/kg daily by gavage 5 times weekly for 63 days.The results showed that M.leprae multiplied well in the foot-pads of untreated mice,but no growth of M.lepare were found in the foot-pads of the mice treated with home-made ofloxacin,imported ofloxacin or rifampin until 12 months after infection of M.leprae.Eleven newly diagnosed and untreated BL/LL patients and 2 recently relapsed patients after dapsone monotherapy were treated with home--made ofloxacin 400mg daily 6 times weekly for 12 weeks.The results showed that the skin lesions of all patients markedly improved at the end of therapy.The mean morphological index(MI) in skin smear decreased from 11.89% before therapy to 2.59% at the end of 2 week treatment,and to 0% at the end of 4 week treatment.The mean bacteriological index(MI) decreased from 4.28 before therapy to 3.90 at the end of therapy.During the therapy,4 patients developed type Ⅱ lepra reaction,but all patients tolerated the drug well.The study showed that the therapeutic effect of home-made ofloxacin is similar to that of imported one as reported in the literature.The home-made ofloxacin can be used in multidrug therapy for leprosy.

Key words: Leprosy, Ofloxacin