中华皮肤科杂志 ›› 1997, Vol. 30 ›› Issue (1): 7-9.

• 论著 • 上一篇    下一篇

江苏籍汉族系统性红斑狼疮与HLA-DR基因的相关性研究

彭学标1, 徐文严1, 岳晓玉1, 费虹明2   

  1. 1. 中国医学科学院、中国协和医科大学皮肤病研究所, 南京 210042;
    2. 上海第二医科大学分子遗传学实验室
  • 收稿日期:1996-02-02 修回日期:1996-05-08 出版日期:1997-02-15 发布日期:1997-02-15

Study on the Association Between HLA-DR Genes and Systemic Lupus Erythematosus in Jiangsu Chinese

Peng Xuebiao1, Xu Wenyan1, Yue Xiaoyu1   

  1. Institute of Dermatology, Chinese Academy of Medical Scieuces and Peking Union Medical College, Nanjing 210042
  • Received:1996-02-02 Revised:1996-05-08 Online:1997-02-15 Published:1997-02-15

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摘要： 为了探讨HLA-DR基因在系统性红斑狼疮(SLE)易感性中的作用,我们用聚合酶链反应(PCR)结合顺序特异的寡核苷酸探针杂交方法对江苏籍汉族SLE患者和正常对照组HLA-DR亚区作寡核苷酸分型.结果显示与正常对照组相比,患者组DR2基因频率明显升高(RR=3.33,PC=2.42×10-3),DR4基因频率则显著降低(RR=0.23,PC=0.0126).提示DR2或某个与DR2紧密连锁的其他基因可能是汉族SLE的易感基因,而DR4对SLE的发病有一定的保护性.

关键词: 红斑狼疮,系统性, HLA-DR, 聚合酶链反应

Abstract: To investigate the predisposing role of HLA-DR genes to systemic lupus erythematosus (SLE), We used polymerase chain reaction and sequence specific oligonucleotide (PCR/SSO) probe hybridization to type HLA-DR subregion in the patients with SLE of Han nationality from Jiangsu province and matched control subjects. The results indicated that DR2 gene frequency was significantly more frequent in patients than that in controls. Whereas DR4 significantly decreased in patients compared with controls. It suggests that DR2 or the other unidentified genes tightly linked to it might be the susceptible genes of SLE. Whereas DR4 might have a protective effect on SLE.

Key words: Lupus erythematosus,systemic, HLA-DR, PCR