中华皮肤科杂志 ›› 1997, Vol. 30 ›› Issue (1): 5-6.

• 论著 •    下一篇

测定系统性红斑狼疮患者狼疮抗凝物质的意义

翁孟武, 苏(女韦), 侯爱琴, 徐明   

  1. 上海医科大学华山医院皮肤科, 200040
  • 收稿日期:1996-08-14 修回日期:1996-11-01 出版日期:1997-02-15 发布日期:1997-02-15

Lupus Anticoagulant Identification in Patients with SLE and Its Clinical Significance

Weng Mengwu, Su Wei, Hou Aiqin   

  1. Department of Dermatology, Hua Shan Hospital, Shanghai Medical University, Shanghai 200040
  • Received:1996-08-14 Revised:1996-11-01 Online:1997-02-15 Published:1997-02-15

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摘要： 目的: SLE患者存在抗磷脂抗体,如狼疮抗凝物质、抗心磷脂抗体等,它与临床上血栓形成、血小扳减少、反复流产、神经系统疾病等密切相关,因此,测定狼疮抗凝物质(LA)对了解疾病的情况具有重要意义.方法: 62例SLE患者的血浆标本,37℃孵育1分钟,加入Lupo-TestⅡ和Lucor试剂,测定凝血所需时间,并计算Lupo-TestⅡ/Lucor比率.结果: 62例SLE患者中LA阳性12例,阳性率19.4%.具有血管炎表现的SLE患者LA阳性率75%(12例中9例阳性),无血管炎表现的SLE患者LA阳性率4%(50例中2例阳性).有或无LA的SLE患者中,ANA、ENA、Ig升高或C3降低的阳性率无显著性差异(P>0.05).结论: 本方法简单,重复性好,在SLE临床研究中具有一定的应用价值.

关键词: 红斑狼疮,系统性

Abstract: Purpose:In SLE patients, it has been reported that antiphospholipid antibodies such as lupus anticoagulant(LA), antieardiolipin antibody (ACA) etc. are closely complicated with thrombosis. thrombocytopenia, reccurrent fetal lost and nervous system disease. Therefore detection of LA is significant to clarify the disease condition. Method:62 plasma specimens from SLE patients were incubated at 37℃ for 1 minute, Lupo-Test Ⅱ and Locor reagent were added, coagulation time determined, and LupoTest/Lueor ratio calculated. Result:The LA positive rate was 19.4%(12/62) in 62 patients with SLE. The Fositive rate of LA in SLE patients with vasculitis was 75% (9/12) and the LA positive rate in SLE patients without vasculitis was 4%(2/50). The positive rates of ANA, ENA, elevated Ig or lower level of C3 were the same in the SLE patients with LA compared with those without LA (P>0.05). The screening tests for LA is simple and reproducible and it may be useful in clinical study of SLE.

Key words: Lupus erythematosus,systemic