中华皮肤科杂志 ›› 2005, Vol. 38 ›› Issue (7): 429-431.

• 论著 • 上一篇    下一篇

假性黑棘皮病肥胖儿童:2型糖尿病的高危人群

傅君芬1, 梁黎1, 董关萍1, 王秀敏1, 郑敏2   

  1. 1. 浙江大学医学院附属儿童医院内分泌科 杭州 310003;
    2. 浙江大学医学院附属第二医院皮肤科 杭州 310003
  • 收稿日期:2004-07-07 发布日期:2005-07-15
  • 基金资助:
    浙江省医药卫生优秀科技人才专项基金(2003QN012); 浙江省科学技术厅项目(2004C30064)

Benign Acanthosis Nigricans in Obese Children:An Indicator for High Risk of Diabetes

FU Jun-fen1, LIANG Li1, DONG Guan-ping1, WANG Xiu-min1, ZHENG Min2   

  1. Department of Endocrinology, Affiliated Children's Hospital of Zhejiang University School of Medicine, Hangzhou 310003, China
  • Received:2004-07-07 Published:2005-07-15

PDF

204

赞

摘要： 目的 探讨肥胖儿童伴假性黑棘皮病与胰岛素抵抗及2型糖尿病的关系。方法 对42例肥胖伴假性黑棘皮病儿童,60例单纯性肥胖儿童及20例正常儿童的空腹血糖及胰岛素水平、空腹血糖/胰岛素比值及人体测量学参数[腰围/臀围比值(wHR)、全身体脂含量、体脂百分数、体质指数]进行分析比较,并对肥胖伴假性黑棘皮病儿童组与单纯性肥胖儿童组行葡萄糖耐量试验,以比较两组患儿的糖耐量异常情况。结果 假性黑棘皮病组有2例诊断为2型糖尿病,21例糖耐量异常,明显高于单纯肥胖儿童组;葡萄糖耐量试验提示60min及120min的血糖水平显著高于单纯肥胖组(P<0.01)。人体测量学参数包括腰围/臀围比值、全身体脂含量、体脂百分数、体质指数及空腹血胰岛素水平明显高于单纯性肥胖组(P<0.01)和对照组(P<0.01),空腹血糖/胰岛素比值明显低于单纯肥胖组(P<0.0I)和对照组(P<0.01)。结论 儿童假性黑棘皮病与肥胖、高胰岛素血症、胰岛素抵抗密切相关,是发生2型糖尿病的高危人群。

关键词: 儿童, 棘皮症,黑, 胰岛素抗药性, 糖尿病,非胰岛素依赖型

Abstract: Objective To explore the relationship between obese children with benign acanthosis nigricans and insulin-resistant and type 2 diabetes mellitus.Methods Levels of glucose,insulin,and glucose/insulin ratio were measured on fasting blood specimens,and anthropometric parameters including waist/hip ratio,fat mass,body fat percentage and body mass index were examined in 42 obese children with benign acanthosis nigricans,60 cases of simple obesity and 20 healthy children controls.Glucose tolerance tests were performed in groups of obese children with benign acanthosis nigricans and simple obesity,respectively.Results Two of 42 obese children with benign acanthosis nigricans were diagnosed as type 2 diabetes mellitus.The rate of abnormal glucose tolerance and levels of blood sugar during 60 min and 120 min after glucose tolerance were significantly higher in acanthosis nigricans children than those in simple obesity (P<0.01).Anthropometric parameters and insulin level in fasting blood were significantly higher in acanthosis nigricans than those in simple obesity (P<0.01)and healthy controls (P<0.01),respectively.Fasting glucose to insulin ratio (FGIR) was significantly lower in acanthosis nigricans than that in simple obesity (P<0.01) and healthy controls (P<0.01),respectively.Conclusion Children with benign acanthosis nigricans are closely associated with obesity,hyperinsulinemia,insulin resistance,and are at high risk of developing type 2 diabetes mellitus.

Key words: Child, Acanthosis nigricans, Insulin resistance, Diabetes mellitus,non-insulin-dependent