中华皮肤科杂志 ›› 1999, Vol. 32 ›› Issue (1): 6-8.

• 论著 • 上一篇    下一篇

Fas抗原及Fas配体在红斑狼疮患者皮损中的表达

王秀丽, 徐世正, 熊腊元, 周慕先, 何萍   

  1. 湖北医科大学附属第一医院皮肤科 武汉 430060
  • 收稿日期:1998-02-13 修回日期:1998-10-13 出版日期:1999-02-15 发布日期:1999-02-15

Expression of Fas Antigen and Fas-Ligand in Skin Lesions of Patients with Lupus Erythematosus

WANG Xiuli, XU Shizheng, XIONG Layuan   

  1. Department of Dermatology, First Affiliated Hospital, Hubei Medical University, Wuhan 430060
  • Received:1998-02-13 Revised:1998-10-13 Online:1999-02-15 Published:1999-02-15

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摘要： 目的 研究Fas抗原及Fas配体(Fas-L)在红斑狼疮皮损中的表达情况.方法 应用免疫组化技术检测25例系统性红斑狼疮(SLE)及14例盘状红斑狼疮(DLE)不同病程的皮损中Fas抗原及Fas-L的表达.结果 SLE及DLE早期皮损角朊细胞Fas抗原表达强度显著高于正常皮肤(P<001),与病程呈负相关(P<005),且真皮中单一核细胞亦有Fas抗原表达;红斑狼疮患者皮损及正常皮肤的角朊细胞均不表达Fas-L,仅在早期皮损真皮内单一核细胞表达Fas-L.结论 Fas系统在角朊细胞及真皮异常表达可能与红斑狼疮皮损发生、发展有关.

关键词: 红斑狼疮,系统性, 红斑狼疮,盘状, 角蛋白细胞, Fas

Abstract: Objective To investigate the expression of Fas antigen and Fas ligand (Fas-L) protein in the skin lesions of patients with lupus erythematosus Methods An immunohistochemical technique was performed for detecting Fas antigen and Fas-L expression in the skin lesions of 25 cases of systemic lupus erythematosus (SLE) and 14 cases of discoid lupus erythematosus (DLE) Results The positive Fas stains were observed in keratinocytes of early skin lesions of both DLE and SLE,and were significantly stronger than those of normal skin (P<0.01),and the expression was negatively related to the course of the disease (P<0.05) Positive Fas stains were also found in mononuclear cells(MNCs) of dermis However,Fas-L was not expressed in keratinocytes in both skin lesions and normal skin of DLE and SLE,only existed in MNCs of dermis in early stage lesions Conclusion The abnormal expression of Fas and Fas-L in keratinocytes and dermal MNCs might be related to the occurrence and development of lupus skin lesions in both DLE and SLE

Key words: Lupus erythematosus,systemic, Lupus erythematosus,discoid, Keratinocytes, Fas