中华皮肤科杂志 ›› 2000, Vol. 33 ›› Issue (3): 157-159.

• 论著 • 上一篇    下一篇

p16基因在尖锐湿疣及其癌变中的意义

苏向阳1, 徐广坤1, 苏祖兰2, 赖维1, 陆春1   

  1. 1. 中山医科大学附属第三医院皮肤性病科 广州 510630;
    2. 中山医科大学附属第三医院病理科
  • 收稿日期:1999-05-31 出版日期:2000-06-15 发布日期:2000-06-15

Significance of p16 Gene in Condyloma Acuminatum

SU Xiangyang1, XU Guangkun1, SU Zhulan2   

  1. Department of Dermatology and Venereology, The Third Affiliated Hospital, Sun Yet-Sen University of Medical Sciences, Guangzhou 510630
  • Received:1999-05-31 Online:2000-06-15 Published:2000-06-15

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摘要： 目的 探讨p16基因在尖锐湿疣及其癌变中的作用及临床意义.方法 应用聚合酶链-单链构象多态性分析(PCR-SSCP)检测33例尖锐湿疣和7例尖锐湿疣癌变患者p16基因有无纯合性缺失和点突变.结果 p16基因在尖锐湿疣及其癌变中存在纯合性缺失,而且缺失程度在尖锐湿疣癌变中明显升高,且是尖锐湿疣癌变的早期表现;未发现p16基因点突变.结论 尖锐湿疣及其癌变与抑癌基因p16失活有关,临床上通过对尖锐湿疣患者p16基因的检测,有可能对尖锐湿疣癌变作出可能性预测及早期诊断,为发现癌变高危人群提供新的依据.

关键词: 尖锐湿疣, 基因,p16

Abstract: Objective To investigate the clinical significance of p16 gene in condyloma acuminatum (CA) and the role in its canceration.Methods Both homologous deletion and mutation of p16 gene were tested in 33 CA samples and 7 samples of CA with canceration by polymerase chain reaction-single strand conformation polymorphism(PCR-SSCP).Results The homologous deletion of p16 gene occurred in CA and CA with canceration.The deletion rate of p16 gene increased significantly in CA with canceration,and homologous deletion of p16 gene was found in the early stage of CA with canceration.There was no mutation of p16 gene in CA and its canceration.Conclusion The change of p16 gene is related to CA and its canceration.Detecting p16 gene in CA patients might be used to find high risk canceration group.

Key words: Condylomata acuminata, Genes,p16