中华皮肤科杂志 ›› 2000, Vol. 33 ›› Issue (3): 155-156.

• 论著 • 上一篇    下一篇

尖锐湿疣患者血清白介素18与γ干扰素水平的检测及其相关研究

钱起丰   

  1. 深圳市皮肤病防治研究所 518020
  • 收稿日期:1999-10-25 出版日期:2000-06-15 发布日期:2000-06-15

The Serum Level of Interleukin-18 and Its Correlation with Interferon gamma in Patients with Condyloma Acuminatum

QIAN Qifeng   

  1. Shenzhen Institute of Dermatology, Center for STD Control and Research, Shenzhen 518020
  • Received:1999-10-25 Online:2000-06-15 Published:2000-06-15

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摘要： 目的 研究白介素18(IL-18),γ干扰素(IFN-γ)在尖锐湿疣(CA)发病机理中的作用及它们之间的关系.方法 用双抗体夹心ELISA法检测了36例CA患者血清IL-18、IFN-γ水平.结果 CA患者血清IL-18、IFN-γ水平均明显低于正常人对照组(分别为P<0.05及P<0.01);IL-18与IFN-γ之间呈正相关(P<0.01).结论 CA患者血清IFN-γ水平低下与-18相关;IL-18水平低下所致的一系列细胞免疫反应抑制效应在CA发病机理中起着重要作用.

关键词: 尖锐湿疣, 白细胞介素18, 干扰素γ

Abstract: Objective To study the role of interleukin-18(IL-18) and interferon gamma(IFN-γ) in the pathogenesis of condyloma acuminatum(CA),and the relationship between the two cytokines.Methods The serum levels of IL-18 and IFN-γ were determined by double antibody sandwich enzyme linked immunosorbent assay in 36 patients with CA and in 30 normal controls.Results The serum levels of IL-18 and IFN-γ were significantly lower in CA patients than those in normal controls(P<0.05 and P<0.01,respectively).A significant correlation was found between the serum levels of IL-18 and IFN-γ (P<0.001).Conclusion The results indicate that the lower level of IFN-γ is related to IL-18,which may result in inhibitory effects on a series of cell-immune response and may play an important role in the pathogenesis of CA.

Key words: Interferon-gamma, Condyloma acuminata, Interleukin-18