中华皮肤科杂志 ›› 2000, Vol. 33 ›› Issue (4): 254-256.

• 论著 • 上一篇    下一篇

不同肤色人种角层细胞黑素含量和形态的比较

陆洪光1, Pearse A2, Marks R2   

  1. 1. 贵阳医学院附属医院皮肤科 贵州省 550001;
    2. 英国威尔士大学医学院Health医院皮肤科
  • 收稿日期:1999-09-07 出版日期:2000-08-15 发布日期:2000-08-15

Racial Differences of Melanin Content and Morphology in Surface Corneocytes--A Comparison Between Black, White and Oriental Skins

LU Hongguang1, PEARSE A2, MARKS R2   

  1. Department of Dermatology, Affiliated Hospital, Guiyang Medical College, Guiyang 550001
  • Received:1999-09-07 Online:2000-08-15 Published:2000-08-15

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摘要： 目的 探讨种族间皮肤角层细胞黑素的差异。方法 用浅表角层细胞粘附技术和OptomaxV计算机分析系统对一组黑种人(10名),白种人(24名)和黄种人(13名)暴光区和非暴光区皮肤浅表角层黑素细胞进行定量分析和观察。结果 3个种族间皮肤浅表角层细胞黑素含量存在明显差异(暴光区F=12.4,P<0.01;非暴光区F=9.89,P<0.01)。3种皮肤浅表角层细胞黑素水平的高低与肤色深浅有密切关系。白种人与黄种人皮肤暴光部位浅表角层细胞黑素含量均显著高于相应肤色的非暴光部位(P均<0.01),黑种人两个部位比较差异无显著性。同时观察到黑种人黑素颗粒较大,呈棕色、棕黑或黑色;黄种人黑素颗粒较黑种人小,较白种人略大,呈浅棕色、棕色或棕黑色;白种人黑素颗粒较细小,呈淡红色,黄红色或红棕色。较深肤色人种浅表角层细胞中可以观察到黑素颗粒向细胞中心集聚的帽状结构。这种现象在黑种人和黄种人的暴光部位和非暴光部位均存在,尤以暴光部位较明显,而白种人仅在暴光部位偶可见到。结论 黑种人、白种人和黄种人浅表角层细胞黑素水平、形态分布的差异反映了人种间皮肤对日光幅射反应能力的差异。

关键词: 种族世系, 黑素类, 角蛋白细胞, 图像处理,计算机辅助

Abstract: Objective To study the differences of melanin content and morphology in surface corneocytes between Black, White and Oriental skins. Methods Melanin content and distribution in surface corneocytes were measured by adhesive slide technique and Optomax V image analysis system in the exposed and unexposed skins from 10 Black Africans, 24 White Caucasians and 13 Orientals. Results There was significant difference of melanin levels in corneocytes among subjects with the three types of skin colour in both exposed areas (F=12.4,P<0.01)and unexposed areas (F=9.89, P<0.01),which correlated with the degree of melanin pigmentation of different race skins. It was also shown that melanin contents were higher in the exposed skin than those in unexposed skin in two racial groups (t=3.25, P<0.01), in Caucasians; t=3.31,P<0.01 in Orientals) except Blacks (t=1.22,P>0.05). It was observed that melanin granules were lighter in colour and smaller in size in corneocytes from Orientals than those from Blacks, but darker in colour and bigger in size than those from Whites.'Cap like structure' of melanin was seen in the cells from the pigmented skin. Conclusions The differences of melanin content and distribution in the corneocytes among Black, White and Oriental skins reflect different melanogenic capability to exposure of sunlight.

Key words: Racial stocks, Melanins, Keratinocytes, Image processing,computer assisted