中华皮肤科杂志 ›› 2001, Vol. 34 ›› Issue (4): 260-262.

• 论著 • 上一篇    下一篇

神经精神性红斑狼疮的抗活化蛋白C研究

李向培1, 厉小梅1, 汪国生1, 周志中2, 陈育华3, 吴竞生2   

  1. 1. 安徽省立医院风湿科 合肥市 230001;
    2. 安徽省立医院中心实验室 合肥市 230001;
    3. 安徽省立医院B超室 合肥市 230001
  • 收稿日期:2000-08-09 出版日期:2001-08-15 发布日期:2001-08-15
  • 基金资助:
    安徽省自然科学基金资助项目(98452234)

Study on Activated Protein C in Patients with Neuropsychiatric Lupus Erythematosus

LI Xiangpei1, LI Xiaomei1, WU Jingsheng1   

  1. Anhui Provincial Hospital, Hefei 230001, China
  • Received:2000-08-09 Online:2001-08-15 Published:2001-08-15

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摘要： 目的 探讨神经精神性红斑狼疮患者抗活化蛋白C现象及抗磷脂抗体在神经精神性红斑狼疮发病中的意义。方法 21例神经精神性红斑狼疮和88例非神经精神性红斑狼疮患者受检。活化的部分凝血活酶时间±活化蛋白C检测抗活化蛋白C,ELISA检测抗心磷脂抗体IgG、IgM、IgA;血浆部分凝血活酶时间-红斑狼疮抗凝物法检测红斑狼疮抗凝物。结果 神经精神性红斑狼疮组抗活化蛋白C阳性率高达78.9%(15/19)、非神经精神性红斑狼疮组抗活化蛋白C阳性率为44.3%(39/88),两组比较差异有显著性(P<0.05)。神经精神性红斑狼疮组与非神经精神性红斑狼疮组IgG型抗心磷脂抗体相比,阳性率分别为52.4%(11/21)和22.7%(20/88),两组比较差异有显著性(P<0.05)。结论 抗活化蛋白C及IgG型抗心磷脂抗体在神经精神性红斑狼疮中有较高的发生率,抗心磷脂抗体引起的获得性抗活化蛋白C可能是神经精神性红斑狼疮发病的重要原因之一。

关键词: C抵抗, 抗体,抗磷脂, 红斑狼疮,系统性, 活化蛋白

Abstract: Objective To explore the significance of activated protein C resistance (APCR) and antiphospholipid antibody(APA) in patients with neuropsychiatric lupus erythematosus(NPLE). Methods APCR, anticardiolipid antibody (ACA)(IgG, M, A), lupus anticoagulant (LA) were measured with APTT±APC, ELISA, PTT-LA methods, respectively, in 21 NPLE patients and 88 SLE patients without NPLE(NNPLE). Results The positive rates of APCR and ACA(IgG) in NPLE group were 78.9% (15/19) and 52.4% (11/21), respectively, which were significantly higher than those in NNPLE group:44.3% (39/88) and 22.7% (20/88), respectively (P<0.05). Conclusion High prevalences of APCR and ACA-IgG are found in NPLE group. The acquired APCR induced by ACA may be a major factor of pathogenic mechanism in NPLE.

Key words: Lupus erythematosus,systemic, Activated protein C resistance, Antibodies,antiphospholipid