中华皮肤科杂志 ›› 2001, Vol. 34 ›› Issue (6): 430-431.

• 论著 • 上一篇    下一篇

白癜风患者血浆与皮肤组织液β-内啡肽水平测定

赵达明, 高明阳, 涂彩霞   

  1. 辽宁省大连医科大学附属第一医院皮肤科
  • 收稿日期:2001-01-15 出版日期:2001-12-15 发布日期:2001-12-15
  • 基金资助:
    辽宁省科委课题(972290)

Plasma and Skin Tissue Fluid Levels of beta-endorphin in Patients with Vitiligo

ZHAO Daming, GAO Mingyang, TU Caixia   

  1. Department of Dermatology, First Affiliated Hospital of Dalian Medical University, Dalian 116011, China
  • Received:2001-01-15 Online:2001-12-15 Published:2001-12-15

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摘要： 目的 探讨β-内啡肽在白癜风发病中的作用。方法 以125I放免药盒检测了40例白癜风患者血浆及其中33例患者皮肤组织液β-内啡肽水平。结果 白癜风泛发型(11.74±3.47pmol/L,以下单位同)、局限型(8.31±2.57)与节段型(8.61±2.61)患者血浆β-内啡肽水平明显高于正常对照组(6.69±1.46).局限型与节段型白癜风皮损处皮肤组织液β-内啡肽水平(分别为9.25±4.49,10.24±4.37)明显高于非皮损处(分别为5.50±2.84,6.12±1.61).泛发型患者皮损处与非皮损处组织液β-内啡肽水平均有升高,二者差异无显着性。结论 β-内啡肽可能在白癜风的发病过程中起一定作用。

关键词: 白癜风, β内啡肽

Abstract: Objective To study the role of beta endorphin (β-EP) in the pathogenesis of vitiligo. Methods Radioimmunoassay (RIA) was used to measure the levels of β-EP in plasma from 40 patients and tissue fluid of lesional and non lesional skin from 33 patients with vitiligo. Results Plasma levels of β-EP were significantly higher in patients with generalized(11.74±3.47 pmol/L), local(8.31±2.57) and segmental(8.61±2.61) vitiligo than those in normal controls(6.69±1.46). Tissue fluid levels of β-EP were significantly higher in lesional skin (9.25±4.49 and 10.24±4.37) than those in non lesional skin (5.50±2.84 and 6.12±1.61) from patients with local and segmental vitiligo. Increased levels of β-EP were observed in tissue fluid from both lesional and non lesional skin in patients with generalized vitiligo, however, no significant difference of β-EP levels was found between the two kinds of skin tissue. Conclusion It is suggested that β-EP might play a role in the pathogenesis of vitiligo.

Key words: Vitiligo, Beta-endorphin