中华皮肤科杂志 ›› 2002, Vol. 35 ›› Issue (1): 20-21.

• 论著 • 上一篇    下一篇

系统性红斑狼疮患者血清几种趋化因子的检测

王建有, 郑敏, 严建良, 刘伦飞, 陈积愫   

  1. 浙江大学医学院附属第二医院皮肤科, 杭州310009
  • 收稿日期:2001-05-15 出版日期:2002-02-15 发布日期:2002-02-15
  • 基金资助:
    浙江省自然科学基金(编号399126);医院学科发展基金资助

Serum Levels of Chemokines in the Patients With Systemic Lupus Erythematosus

WANG Jianyou, ZHENG Min, YAN Jianliang, LIU Lunfei, CHEN Jisu   

  1. Department of Dermatology and Venereology, The Second Affiliated Hospital, Medical School of Zhejiang University, Hangzhou 310009, China
  • Received:2001-05-15 Online:2002-02-15 Published:2002-02-15

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摘要： 目的 探讨血清趋化因子单核细胞趋化及活化因子/单核细胞趋化蛋白-1(MCAF/MCP-1)、正常T细胞表达和分泌的活化调节蛋白(RANTES)水平与系统性红斑狼疮疾病活动程度的关系及意义。方法 采用双抗体夹心ELISA法检测血清MCAF、RANTES水平。结果 ①SLE患者血清MCAF水平明显高于正常人;②活动期患者血清MCAF水平明显高于非活动期;③肾损组与非肾损组相比,血清MCAF、RANTES水平差异均无显着性。结论 趋化因子MCAF可能参与系统性红斑狼疮的发病机制,且血清MCAF水平可作为反映疾病活动性的一个指标。

关键词: 红斑狼疮,系统性, 趋化因子类

Abstract: Objective To determine the relationship between serum levels of MCAF/MCP-1 (monocyte chemotactic and activating factor/monocyte chemoattractant protein-1), RANTES(regulated on activation, normal T-cell expressed and secreted) and the disease activity of systemic lupus erythematosus(SLE). Methods Serum levels of MCAF and RANTES were measured by ELISA. Results ①Serum level of MCAF but not RANTES, was significantly increased in patients with SLE as compared with controls. ②Serum level of MCAF but not RANTES, was markedly higher in patients with active disease than those with inactive disease. ③No significant differences were found in the serum levels of MCAF and RANTES between patients with renal damage and those without. Conclusions These results suggest that MCAF may be involved in the pathogenesis of SLE, and serum MCAF levels could be an indicator for the disease activity of SLE.

Key words: Lupus erythematosus, systemic, Chemokines