中华皮肤科杂志 ›› 2002, Vol. 35 ›› Issue (4): 290-292.

• 中医中药 • 上一篇    下一篇

已治早期显性梅毒患者血清RPR试验和梅毒螺旋体IgM抗体检查联合随访

施辛, 黄宏, 吾为一, 杨辰, 顾爱萍, 苏玉华, 刘秀丽   

  1. 苏州大学附属第二医院 215004
  • 收稿日期:2002-01-11 出版日期:2002-08-15 发布日期:2002-08-15

Following-up of Early Syphilis with both RPR Test and Tp-IgM-Capture-EL ISA after Treatment

SHI Xin, HUANG Hong, WU Weiyi, YANG Chen, GU Aiping, SU Yuhua, LIU Xiuli   

  1. Second Affiliated Hospital of Suzhou University, Suzhou 215004, China
  • Received:2002-01-11 Online:2002-08-15 Published:2002-08-15

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摘要： 目的 探讨RPR试验和梅毒螺旋体(Tp)IgM抗体试验联合检测对于早期梅毒的随访意义.方法 病史在1年以内的61例一期梅毒患者和77例二期梅毒患者,于治疗后,每3个月接受RPR试验和梅毒螺旋体IgM抗体捕获ELISA联合检测,为时2年.结果 RPR试验不同时间的转阴率分别为6.2%(3个月时)、31.5%(6个月时)、61.5%(9个月时)、83.8%(12个月时)、90.7%(15个月时)、92.3%(18个月时)、94.6%(21个月时)、95.3%(24个月时).Tp-IgM检查不同时间的转阴率分别为25.4%(3个月时)、56.5%(6个月时)、86.2%(9个月时)、97.1%(12个月时)、100.0%(15个月时).其中,一期梅毒RPR试验不同时间的转阴率分别为8.2%(3个月时)、31.1%(6个月时)、57.4%(9个月时)、75.4%(12个月时)、83.6%(15个月时)、85.2%(18个月时)、100.0%(21个月时),Tp-IgM检查不同时间的转阴率分别为45.9%(3个月时)、85.2%(6个月时)、98.4%(9个月时)、100.0%(12个月时).二期梅毒RPR试验不同时间的转阴率分别为2.6%(3个月时)、28.6%(6个月时)、58.4%(9个月时)、81.8%(12个月时)、84.4%(15个月时)、88.3%(18个月时)、90.9%(21个月时)、92.2%(24个月时),Tp-IgM检查不同时间的转阴率分别为9.1%(3个月时)、33.8%(6个月时)、71.4%(9个月时)、94.8%(12个月时)、100.0%(15个月时).Tp-IgM检查转阴均早于RPR试验所检测的反应素转阴.Tp-IgM没有出现血清固定现象结论 Tp-IgM检查在治疗后12个月左右应该消失.在一定程度上,梅毒螺旋体IgM抗体捕获ELISA有益于早期显性梅毒的随访.

关键词: 梅毒, 反应素类, IGM, 密螺旋体,苍白, 酶联免疫吸附测定

Abstract: Objective To explore the significance of RPR test and Tp-IgM-Capture-ELISA in following-up of early syphilis.Methods Sixty-one cases of primary syphilis with less than one-year course and 77 cases of secondary syphilis were enr olled into the study.The patients were followed up by RPR test and Tp-IgM-Capture-ELISAat intervals of three months for two years after treatment.Results By the end of 3,6,9,12,15,18,21 and 24 months,RPR test became negative in 6.2%,31.5%,61.5%,83.8%,90.7%,92.3%,94.6%,and 95.3% of patients,respectively.By the end of 3,6,9,12and 15months,Tp-IgM-Capture-ELISA became negative in 25.4%,56.5%,86.2%,97.1% and 100.0% of patients,respectiv ely.In primary syphilis the RPR test became nonreactive in 8.2%(3months after treatment),31.1%(6months),57.4%(9months),75.4%(12months),83.6%(15months),85.2%(18months),and 100.0%(21months)of patients,and Tp-IgM-Capture-ELISA in 45.9%(3months),85.2%(6months),98.4%(9months),100.0%(12months)of patients.In secondary syphilis RPRtest became n onreactive in 2.6%(3months after treatment), 28.6%(6months), 58.4%(9months), 81.8%(12months), 84.4%(15months), 88.3%(18months), 90.9%(21months) and 92.2%(24months)of patients,and Tp-IgM-Capture-ELISAin 9.1%(3months), 33.8%(6months), 71.4%(9months), 94.8%(12months) and 100.0%(15months)of patients.Tp-IgM-Capture-ELISA was found to be negative earlier than that of RPR test in all cases.No sero-resistant was shown in Tp-IgM-Capture-ELISA.Conclusions Tp-IgM turns to negative in 12months after treatment for nearly all patients with early syphilis.Tp-IgM-Capture-ELISA may be served as a useful tool to follow up early syphilis patients after treatment.

Key words: Syphilis, Reagins, IgM, Treponema pallidum, Enzyme-linked immunosorbent assay