中华皮肤科杂志 ›› 2002, Vol. 35 ›› Issue (5): 393-395.

• 论著 • 上一篇    下一篇

A型肉毒毒素治疗Meige综合征及面部皮肤除皱临床研究

邓远飞, 王成林   

  1. 北京大学深圳医院, 深圳518036
  • 收稿日期:2002-03-04 出版日期:2002-10-15 发布日期:2002-10-15
  • 基金资助:

    广东省医学科学技术研究基金资助项目(A1998009)

Botulinum Toxin Type A Therapy in Meige’s Syndrome and Facial Wrinkles

DENG Yuanfei, WANG Chenglin   

  1. Beijing University Shenzhen Hospital, Shenzhen 518036, China
  • Received:2002-03-04 Online:2002-10-15 Published:2002-10-15

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摘要：

目的 观察A型肉毒毒素(BTXA)治疗Meige综合征及面部皮肤除皱的疗效,探讨降低药物副作用的发生及BTXA皮肤除皱的作用。方法 对99例患者应用BTXA局部多点注射。结果 治疗眼睑痉挛型、口下颌肌张力障碍型及眼睑痉挛并口下颌肌张力障碍型的显效率分别为98.4%、90.9%和95.8%.疗效持续时间分别为(16.9±8.4)周、(12.6±5.4)周和(13.5±5.7)周。面部皮肤除皱有效率100%,皮纹变浅、变平且光滑。局部副作用轻微、短暂且可自行消失。结论 BTXA治疗Meige综合征及面部皮肤除皱疗效显着且安全性好。严格操作规程及掌握适当剂量能降低药物副作用的发生。

关键词: 肉毒杆菌毒素,A型, Meige综合征, 皮肤衰老

Abstract:

Objective To observe the efficacy of Botulinum toxin type A(BTXA)injection in Meige's syndrome and facial wrinkles and explore the method of reducing the side effect of BTXA and weaken facial wrinkles.Methods Ninety-nine patients were evaluated on the therapeutic efficacy of single and multiple topical facial injection with BTXA.Results The effective rates of patients with blepharospasm were 98.4%,oromandi bular dystonia 90.9%,blepharospasm and oromandibular dystonia 95.8%,respectively.The therapeutic effect for each disease lasted(16.9±8.4)weeks、(12.6±5.4)weeks and(13.5±5.7)weeks,respectively.Facial wrinkles of all patients has got weakened and seemed much smooth and flattend.The recovery rate approached to 100%.The local side effects were transient and mild,and disappeared spontaneously.Conclusions The treatment of Meige's syndrome and facial wrinkles with BTXA could produce a significant improvement,and is safe.Strictly observe the procedures of injection,and use adequate dose of BTXA,the side effects of BTXA can be decreased.

Key words: Botulinum toxin type A, Meige’s syndrome, Skin aging