中华皮肤科杂志 ›› 2002, Vol. 35 ›› Issue (6): 455-456.

• 论著 • 上一篇    下一篇

系统性红斑狼疮患者皮损中核因子-κB表达水平的初步研究

方春红, 梁虹, 李建军, 徐红新, 熊腊元   

  1. 武汉大学人民医院皮肤科 430060
  • 收稿日期:2001-02-20 出版日期:2002-12-15 发布日期:2002-12-15
  • 基金资助:
    湖北省教育厅杰出青年人才基金部分资助(99B101)

Study on Nuclear Factor-κB Activation in Skin Lesions of Systemic Lupus Eryt hematosus

FANG Chunhong, LIANG Hong, LI Jianjun, XU Hongxin, XIONG Layuan   

  1. Department of Dermatology, Renmin Hospital, Wuhan University School of Medicine, Wuhan 430060, China
  • Received:2001-02-20 Online:2002-12-15 Published:2002-12-15

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摘要： 目的 观察系统性红斑狼疮(SLE)患者皮损中核因子-κB(NF-κB)的表达情况及与病情活动的关系.方法 取15例SLE患者典型皮损进行石蜡切片、免疫组化染色,观察其阳性表达颜色的深浅并进行半定量分析.结果 15例SLE患者典型皮损中14例NF-κBp65表达阳性,8例+++,3例++,3例+,阳性细胞见于表皮角质形成细胞及真皮单一核细胞,其中以棘层细胞及颗粒层细胞的细胞核中表达较强,而非SLE患者正常皮肤中则未见明显的NF-κBp65表达阳性细胞,且皮损中NF-κB表达与疾病活动无明显关系.结论 SLE患者皮肤损害的发生与局部NF-κB的异常激活有一定关系,但似与疾病活动无关.

关键词: 红斑狼疮,系统性, NF-κB

Abstract: Objective To examine whether activation of nuclear factor-κB (NF-κB) exists in skin lesions of patients with systemic lupus erythematosus (SLE) and its association with disease activity. Methods The skin lesions were inves tigated histopathologically in patients with SLE, and NF-κB activation was ass essed by immunohistochemical analysis semi quantitatively. Results Expression o f NF-êB was found on skin lesions in 14 of 15 patients with SLE, including 8 s trong positive (+++), 3 moderate positive (++), and 3 mild positive (+). Brown-coloured particles were mainly distributed in keratinocytes, especially in prick lecells and granular layer cells, as well as in mononuclear cells of dermis. Th ere was no correlation between NF-κB activation and disease activity. However, NF-êB was not detected in skin lesions of all patients with non-SLE and healthy controls. Conclusions NF-κB activation may be associated with the development of skin lesions in patients with SLE,and not with disease activity.

Key words: Lupus erythematosus, systemic, NF-kappa B