中华皮肤科杂志 ›› 2003, Vol. 36 ›› Issue (4): 195-197.

• 论著 • 上一篇    下一篇

p53、增殖细胞核抗原和Bcl-2在皮肤外毛根鞘癌中的表达

葛霞, 谢群, 姚敏   

  1. 安徽省蚌埠医学院病理教研室 233003
  • 收稿日期:2002-04-17 出版日期:2003-04-15 发布日期:2003-04-15

Expression of p53,PCNA and Bcl-2in Trichilemmal Carcinoma of Skin

GE Xia, XIE Qun, YAO Min   

  1. Department of Pathology, Bengbu Medical College, Bengbu, Anhui 233003, China
  • Received:2002-04-17 Online:2003-04-15 Published:2003-04-15

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摘要： 目的 探索外毛根鞘癌的临床病理学特征及p53、增殖细胞核抗原(PCNA)和Bcl-2的表达与意义。方法 应用HE染色观察和免疫组化S-P方法检测22例外毛根鞘癌p53、PCNA和Bcl-2蛋白表达。结果 22例外毛根鞘癌患者中女15例,男7例,年龄40~79岁,发生于头顶枕部皮肤16例。免疫组化标记结果显示:p53阳性表达为72%(16/22),阳性分布广泛;PCNA全部阳性,但阳性细胞在高中低分化中呈递增趋势;Bcl-2阳性为63%,在各级之间表达差异有显著性(P<0.01)。结论 分叶状结构和骤然角化是外毛根鞘癌的组织学特征;p53、PCNA、Bcl-2在外毛根鞘癌均有不同程度的表达,参与肿瘤发生发展和生长调控。

关键词: 皮肤肿瘤, 外毛根鞘癌, 蛋白质p53, 增殖细胞核抗原

Abstract: Objective To investigate the clinicopathologic features and the expression of p53,PCNA and Bcl-2 in tricholemmal carcinoma.Methods Skin lesions were studied with HE staining and immunohistochemical markers for p53,PCNA and Bcl-2(S-P method)in 22 cases of skin tricholemmal carcinoma.Both morphological manifestations and immunohistochemical expression were observed.Results There were 15 female and 7 male cases of tricholemmal carcinoma with the ages of 40-79y,including16cases whose scalp were involved.Positive staining of p53,PCNA and Bcl-2 was found in 72%,100% and 63% of patients,respectively.The positive cells of p53 were diffusely distributed.PCNA-positive cells were increased along with the degree of differentiation.Significant differences of Bcl-2 expression were found among the various degrees of differentiation (P<0.01). Conclusions The lobulated construction and abrupt keratinization are hitological features of tricholemmal carcinoma.Different degrees of expression of p53,PCNA and Bcl-2 might take part in neoplastic development and control.

Key words: Skin neoplasms, Tricholemmal carcinoma, Protein p53, Proliferating cell nuclear antigen