中华皮肤科杂志 ›› 2004, Vol. 37 ›› Issue (5): 268-269.

• 论著 • 上一篇    下一篇

复发性生殖器疱疹患者外周血单一核细胞CD40和CD40L的表达

邓云华, 陈兴平, 许成蓉, 陈映玲   

  1. 华中科技大学同济医学院附属同济医院皮肤科, 武汉430030
  • 收稿日期:2003-05-18 出版日期:2004-05-15 发布日期:2004-05-15

Expression of CD40 and CD40L on Peripheral Blood Mononuclear Cells in Patients with Recurrent Genital Herpes

DENG Yun-hua, CHEN Xing-ping, XU Cheng-rong, CHEN Ying-ling   

  1. Department of Dermatology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
  • Received:2003-05-18 Online:2004-05-15 Published:2004-05-15

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摘要： 目的 探讨复发性生殖器疱疹患者外周血单一核细胞CD40、CD40L的表达。方法 利用流式细胞仪对30例复发性生殖器疱疹患者和20例正常人对照者外周血单一核细胞(PBMC)CD40、CD40L的表达及T淋巴细胞亚群进行检测。结果 病例组PBMC中CD40阳性细胞百分数较对照组显著降低(P=0.0061);CD40L阳性细胞百分数较对照组明显降低(P=0.041);CD3+T细胞和CD4+T细胞百分数亦显著低于对照组(其P值分别为0.025和0.032)。结论 CD40-CD40L共刺激作用低下是生殖器疱疹复发的重要原因之一。

关键词: 疱疹,生殖器, CD40配体, T淋巴细胞, 抗原,CD40

Abstract: Objective To investigate the expression of CD40/CD40L on peripheral blood mononuclear cells (PBMC) in patients with recurrent genital herpes (RGH). Methods Flow cytometric analysis was employed to identify the expression of CD40 and CD40L on PBMC and the T lymphocyte subgroups in the peripheral blood of 30 patients with RGH and 20 healthy controls. Results Percentage of the cells with either CD40 or CD40L expression in the patients with RGH was significantly lower than that in the controls (P=0.0061 and 0.041, respectively). The RGH group had a significantly lower percentages of CD3+ T cells (P=0.025) and CD4+ T cells (P=0.032) as compared to the controls. Conclusion Reduced costimulatory interaction of CD40 and CD40L in RGH patients may be one of the important factors for the recurrence.

Key words: CD40 ligand, T-lymphocytes, Herpes, genitals, Antigens, CD40