中华皮肤科杂志 ›› 2004, Vol. 37 ›› Issue (12): 712-714.

• 论著 • 上一篇    下一篇

梅毒患者皮损中Th1/Th2细胞因子表达与RPR试验阴转的关系

周平玉1, 熊思东2, 阎春林3, 徐金华3, 廖康煌3   

  1. 1. 上海市皮肤病性病医院性病研究室 200050;
    2. 复旦大学免疫学系;
    3. 复旦大学华山医院皮肤科
  • 收稿日期:2004-02-12 出版日期:2004-12-15 发布日期:2004-12-15
  • 基金资助:
    上海市科学技术发展基金资助(项目号401)

Expression of Th1/Th2 Cytokines in Early Syphilitic Lesions and Its Relationship with the Sero-conversion of RPR Test in Patients with Syphilis

ZHOU Ping-yu1, XIONG Si-dong2, YAN Chun-lin3, XU Jin-hua3, LIAO Kang-huang3   

  1. Institute of Shanghai Skin & STD Hospital, Shanghai 200050, China
  • Received:2004-02-12 Online:2004-12-15 Published:2004-12-15

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摘要： 目的 了解早期显性梅毒患者皮损中Th1/Th2型细胞因子的表达及其与患者RPR试验阴转的关系.方法 用ABC免疫组化检测30例早期显性梅毒患者皮损中Th1/Th2型细胞因子的表达,并于驱梅治疗结束后的第1,3,6,9,12个月随访这些患者的血清快速血浆反应素环状卡片试验(RPR)情况.结果 10例一期梅毒患者在随访期内血清RPR试验均转阴,皮损中有9例表达Th1/Th2型细胞因子,1例仅有Th1型细胞因子表达;20例二期显性梅毒患者在随访期内血清RPR试验有12例转阴,皮损中16例有Th1/Th2型细胞因子表达,4例仅有Th2型细胞因子表达;早期梅毒皮损Th1型细胞因子的表达与梅毒RPR试验阴转呈正相关,干扰素γ表达越高,血清RPR试验越容易转阴.结论 Th1型细胞因子的早期活化和持续存在在清除局部病原体的过程中起重要作用.

关键词: 梅毒, 白细胞介素2, 白细胞介素4, 白细胞介素10, 干扰素Ⅱ型, 预后

Abstract: Objective To investigate the expression of Th1/Th2 cytokines in early symptomatic syphilitic lesions and its relationship with the sero-conversion of RPR test in patients with syphilis.Methods The expression of Th1/Th2 cytokines in lesions from 30 patients with early symptomatic syphilis was immunohistochemically detected with ABC method.The serum titers of RPR test in these patients were measured in 1, 3, 6, 9 and 12 months after routine benzathine penicillin treatment.Results Among 10 cases of primary syphilis, the express ion of both Th1 and Th2 cytokines in the lesions was found in 9 cases, while only Th1 cytokine expression was observed in the remainder case; and the sero-conversion of RPR test occurred in all 10 cases during the follow-up period.Among 20 cases of secondary syphilis, Th1/Th2 cytokines expressed in the lesions in 16 c ases, and only Th2 cytokines expressed in 4 cases; and the sero-conversion of RP R test was found in 12 cases during the follow-up period.The expression of Th1 cytokines in early syphilitic lesions was positively correlated with the sero-conversion of RPR test.The higher the expression of IFN-γ, the more likely the sero-conversion of RPR test.Conclusion The early activation and persistence of the expression of Th1 cytokines may play an important role in the clearance of pathogens.

Key words: Syphilis, Interleukin-2, Interleukin-4, Interleukin-10, Interferon typeⅡ, Prognosis