中华皮肤科杂志 ›› 2012, Vol. 45 ›› Issue (1): 53-54.

• 临床经验 • 上一篇    下一篇

脐带间质干细胞和脐血干细胞治疗难治性天疱疮一例

王心声1,乔娜1,付萍2,周晓鸿3,王文芳2,邓丹琪4,胡祥5   

  1. 1. 昆明医学院附二院皮肤科
    2. 昆明医学院第二附属医院皮肤科
    3. 昆明医学院第二附属医院皮肤/风湿免疫科
    4. 昆明医学院第二附属医院
    5. 深圳市北科细胞工程研究所
  • 收稿日期:2011-03-18 修回日期:2011-04-22 出版日期:2012-01-15 发布日期:2011-12-31
  • 通讯作者: 付萍 E-mail:cinafuping@hotmail.com

Umbilical cord-derived mesenchymal stem cells and umbilical cord blood-derived stem cells for the treatment of refractory pemphigus: a case report

  • Received:2011-03-18 Revised:2011-04-22 Online:2012-01-15 Published:2011-12-31
  • Contact: fuping pingping E-mail:cinafuping@hotmail.com

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摘要：

天疱疮是一种累及皮肤和黏膜的有潜在致命性的以水疱和溃疡为主要表现的自身免疫性疾病，系统应用糖皮质激素是其主要治疗方法，各种免疫抑制剂是其辅助治疗手段，随着对天疱疮发病机制研究的深入，各种新的治疗方法不断涌现，为探讨脐带间充质干细胞移植治疗天疱疮的可能性，我们应用脐带间充质干细胞移植治疗1例难治性天疱疮患者，取得了满意的近期效果，为天疱疮的治疗开辟了新的途径。

关键词: 天疱疮

Abstract:

Pemphigus variants represent a group of severe and possibly fatal skin disease with blisters and erosions on the skin and /or the oral mucosae. The use of systemic steroid therapy is indispensable for the treatment of pemphigus. Some patients can be treated only with this therapy; however, other cases do not respond to this regimen. as for days Pemphigus pathogenesis of further research, all sorts of new treatments are constantly emerging, to explore the umbilical cord mesenchymal stem cell transplantation for days, the possibility of pemphigus we applied umbilical cord mesenchymal stem cell transplantation for 1 cases refractory days pemphigus patients, and achieved satisfactory effect for days, recent sores blister treatment has opened up a new way.

Key words: Pemphigus