中华皮肤科杂志 ›› 2011, Vol. 44 ›› Issue (11): 786-788.

• 论著 • 上一篇    下一篇

182例红皮病病因与临床特征分析

李凯1,陈柳青2,杨光艳3,邢建军1,4,宋玲娟4,5,罗庆4,6,白静峰4,张良7,曾宪玉2,周小勇1,段逸群2   

  1. 1. 武汉市第一医院
    2. 武汉市第一医院皮肤科
    3. 武汉市一医院
    4.
    5. 现在武汉同和皮肤病医院工作
    6. 现在连云港长寿医院工作
    7. 武汉第一医院
  • 收稿日期:2011-01-04 修回日期:2011-02-16 出版日期:2011-11-15 发布日期:2011-11-01
  • 通讯作者: 段逸群 E-mail:duanyiqun@medmail.com.cn
  • 基金资助:

    中部医疗服务中心3.1.1人才工程

Etiology and clinical features of 182 cases of erythroderma

  • Received:2011-01-04 Revised:2011-02-16 Online:2011-11-15 Published:2011-11-01

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摘要：

目的 探讨红皮病的病因与临床特征的相关性。方法 回顾性分析182例红皮病患者的临床资料。结果 男女之比为2.8 ∶ 1；发病年龄（58.6 ± 14.6）岁。继发于原有皮肤病135例（74.2%），药物过敏14例（7.7%），恶性肿瘤8例（4.4%），原因不明25例（13.7%）。红皮病诱发原因中系统用药诱发比例最高，共52例（28.6%），其中最常见的药物为糖皮质激素。随访76例，58例痊愈后未再发红皮病，再发患者14例，死亡5例，2例不明原因红皮病患者经过多次组织病理检查确诊为蕈样肉芽肿。结论 继发于原有皮肤病是红皮病的最常见原因。原因不明红皮病患者易复发，有伴随恶性肿瘤可能，应密切随访。

关键词: 预后

Abstract:

Objective To study the correlation between the etiology and clinical features of erythroderma. Methods The clinical data on 182 patients with erythroderma were retrospectively collected and analyzed. Results The male-to-female ratio was 2.8 ∶ 1 and the average age at onset was 58.6 ± 14.6 years. Of the 182 cases, 135 （74.2%） were due to pre-existing dermatoses, 14 （7.7%） to drug reaction, 8 （4.4%） to malignancies, while 25 （13.7%） had no obvious precipitating factors. The most frequent triggering factor was systemic consumption of drugs （52 patients, 28.6%）, and glucocorticosteroid was the most prevalent causative drug. Seventy-six patients were followed up, recurrence was observed in 14 patients but not in 58 patients, and 5 patients died, 2 patients with idiopathic erythroderma were finally diagnosed with mycosis fungoides （MF） after multiple skin biopsies. Conclusions Pre-existing dermatoses are the most frequent cause of erythroderma. Idiopathic erythroderma is liable to relapse, possibly associated with malignancies, and should be closely followed up.

Key words: Prognosis