中华皮肤科杂志 ›› 2009, Vol. 42 ›› Issue (11): 779-780.

• 短篇论著 • 上一篇    下一篇

SLE患者过氧化氢酶基因-330位点单核苷酸多态性研究

彭学标1,李富利2   

  1. 1. 南方医科大学南方医院风湿科
    2.
  • 收稿日期:2008-10-10 修回日期:2009-06-14 出版日期:2009-11-15 发布日期:2009-11-13
  • 通讯作者: 彭学标 E-mail:pengxb@fimmu.com
  • 基金资助:

    广东省医学科研基金（A2005408）;省级基金（编号）

Catalase gene-330 single nucleotide polymorphism in patients with systemic lupus erythematosus

  • Received:2008-10-10 Revised:2009-06-14 Online:2009-11-15 Published:2009-11-13

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摘要：

目的 探讨过氧化氢酶(CAT)-330位点单核苷酸多态性与系统性红斑狼疮(SLE)的相关性。方法 用聚合酶链反应（PCR）-限制性片段长度多态性法对CAT基因-330多态性位点作基因分型。结果 患者组和正常对照组间CAT-330CC、-330CT及-330TT基因型频率均无统计学差异，但活动期SLE患者中CAT-330CC基因型频率显著高于静止期SLE患者和正常人对照组，且CAT-330CC基因型与SLE患者肾损害、血液学改变以及抗U1RNP抗体和抗dsDNA抗体产生有关。结论 CAT-330CC基因型与SLE的一些临床特征相关联，拥有CAT-330CC基因型的患者病情严重，预后差。

关键词: 红斑狼疮，系统性, 过氧化氢酶, 多态性，单核苷酸

Abstract:

Relationship between catalase –330 single nucleotide polymorphisms and systemic lupus erythematosus. Peng Xuebiao，Li Fuli. Department of Dermatology,Nanfang Hospital,Nanfang Medical University,Guangzhou,510515,china. [Abstract] Objective To investigate the relationship between catalase –330 single nucleotide polymorphisms and systemic lupus erythematosus. Method CAT -330 polymorphisms was analyzed by polymerse chain reaction-restriction fragment length polymorphism(PCR-RFLP).Results We did not observe significant difference in the prevalence of CAT-330C/T polymorphic variants(CC,CT,TT) in SLE patients and normal controls. However,we found that the CAT-330CC gene frequency was significantly increased in active SLE,compared to in inactive ones and normal controls. We also observed that CAT-330 CC genetype showed a significant association with renal manifestation,blood system changes and presence of anti-dsDNA antibody and anti-U1RNP antibody in the patients with SLE. Conclusion Our findings suggest that CAT-330 genetype may contribute to some clinic manifestations in SLE patients,those patients who have CAT-330CC genetype will suffer from more severe illness and poor prognosis.

Key words: systemic lupus erythematosus, GSH-Px