中华皮肤科杂志 ›› 2009, Vol. 42 ›› Issue (9): 645-646.

• 短篇论著 • 上一篇    下一篇

HLA-DM基因多态性与SLE相关性分析

张峻岭1,廉佳2   

  1. 1. 天津市长征医院
    2. 天津市儿童医院皮肤科
  • 收稿日期:2008-08-19 修回日期:2009-05-21 出版日期:2009-09-15 发布日期:2012-03-21
  • 通讯作者: 张峻岭 E-mail:zhangjunling2005@yahoo.com.cn
  • 基金资助:
    天津市卫生局科技基金

Relationship between HLA-DM gene polymorphism and systemic lupus erythematosus

  • Received:2008-08-19 Revised:2009-05-21 Online:2009-09-15 Published:2012-03-21
  • Contact: Zhang Jun-Ling E-mail:zhangjunling2005@yahoo.com.cn

PDF (PC)

219

赞

摘要： 目的：探讨HLA-DM基因的多态性及其与系统性红斑狼疮（systemic lupus erythematosus ,SLE）的相关性。方法：应用限制性片段长度多态性-聚合酶链反应（RFLP-PCR）技术，检测HLA-DM基因的多态性，继而分析HLA-DM基因多态性与SLE发生的相关性。结果：①共检出HLA-DMA等位基因型4种，基因型6种，HLA-DMB等位基因型3种，基因型6种，HLA-DM单倍型29种。②HLA-DM*0101/0103基因型的分布在SLE组高于健康对照组（P<0.05），余各等位基因型及基因型在两组间的分布差异无显著性。结论：HLA-DM基因多态性与SLE的发生有一定的相关性，HLA-DM*0101/0103基因型可能为SLE的易感基因型。

关键词: 红斑狼疮，系统性, HLA-DM基因

Abstract: Objective: To study the HLA-DM gene polymorphism,and the correlations between HLA-DM gene polymorphism and systemic lupus erythematosus (SLE) . methods:HLA-DM gene polymorphism were detected by restriction fragment length polymorphism - polymerase chain reaction(RFLP-PCR).Then we had analysised the distribution of HLA-DM gene polymorphism between SLE and the health control group. Results: ①Four kinds of HLA-DMA allele genotypes, three kinds of HLA-DMB allele genotypes, six kinds of HLA-DMA genotypes, six kinds of HLA-DMB genotypes, and 29 kinds of HLA-DM haplotypes are detected in SLE group and the healthy control group. ②Among them, the HLA-DMB*0101/0103 genotype frequencies of SLE group is higher than the healthy control group（p<0.05）. Conclusions: HLA-DM gene polymorphism and the incidence of SLE have some relevance, The genotype HLA-DMB*0101/0103 may be one of the susceptible gene of SLE.

Key words: systemic lupus erythematosus