中华皮肤科杂志 ›› 2009, Vol. 42 ›› Issue (4): 263-264.

• 短篇论著 • 上一篇    下一篇

他克莫司治疗外伤所致白癜风前后血清IL-2、TNF-α的观察

杨闰平1,刘元林1,李晓鹏1,俞天峰2   

  1. 1. 海军总医院皮肤科
    2. 解放军91458部队医院
  • 收稿日期:2008-03-12 修回日期:2008-04-25 出版日期:2009-04-15 发布日期:2009-04-14
  • 通讯作者: 杨闰平

Detection of serum interleukin-2 and tumor necrolysis factor-alpha in patients with truma-induced vitiligo before and after the treatment with tacrolimus

  • Received:2008-03-12 Revised:2008-04-25 Online:2009-04-15 Published:2009-04-14

PDF (PC)

209

赞

摘要：

[摘要]目的：外伤致白癜风是由特殊诱因所致，迄今为止发病机理不清楚。为了解新型外用免疫调节剂他克莫司软膏对其的疗效及对其发病的免疫学机制进行初步探讨。 方法：观察脱色斑的复色面积来判断他克莫司的疗效；用ELISA法对12例局部外伤后白癜风患者他克莫司治疗前后血清IL-2和TNF-α进行测定并与正常人的血清含量比较。结果：他克莫司的有效率达75%；外伤后白癜风患者IL-2和TNF-α较正常人显著增高， p<0.05；外用他克莫司治疗4月后，IL-2和TNF-α水平较治疗前无明显的下降，p>0.05。结论：外用免疫调节剂他克莫司软膏治疗安全有效，自身免疫反应在外伤后白癜风的发病中起重要作用。

Abstract:

The Study on Serum IL-2,TNF-a of Patients with Traumatic Vitiligo before and after Treatment with Tacrolimus /Runping YANG, Yunlin LIU,Xiaopeng LI/Depart of Dermatology, General Naval Hospital, Beijing,100037. [Abstract]Objective：Traumatic vitiligo is one type with unusual inducements, whose pathogenesis is still unknown. This article was aimed to observe the efficacy of 0.1%Tacrolimus Ointment on traumatic vitiligo and investigate it’s immunological mechanisms .Methods：The efficacy of tacrolimus was judged by the repigmentation area of the vitiligo lesions; ELISA was applied to quantitatively determine the serum IL-2, TNF-a of patients with traumatic vitiligo before and after treatment with Tacrolimus , and compared with that of normal controls. Results：The efficacy rate of Tacrolimus for traumatic vitiligo was 75%;The serum IL-2,TNF-a of traumatic vitiligo before and after treatment with Tacrolimus were significantly higher than those of controls ,p<0.05. And serum IL-2,TNF-a were not reduced significantly by Tacrolimus by the trial end, p>0.05.Conclusions：Immunomodulator Tacrolimus is effective for traumatic vitiligo;Autoimmune aspects play a vital role in it’s pathogenesis .