保湿剂在特应性皮炎管理中的合理应用专家共识（2026版）

doi:10.35541/cjd.20250050

中华皮肤科杂志 ›› 2026, Vol. 59 ›› Issue (2): 107-112.doi: 10.35541/cjd.20250050

保湿剂在特应性皮炎管理中的合理应用专家共识（2026版）

中国中西医结合学会皮肤性病专业委员会环境与职业性皮肤病学组中国老年保健医学研究会皮肤科分会中国中药协会皮肤病药物研究专业委员会中国人体健康科技促进会皮肤科分会

中国中西医结合学会皮肤性病专业委员会环境与职业性皮肤病学组中国老年保健医学研究会皮肤科分会中国中药协会皮肤病药物研究专业委员会中国人体健康科技促进会皮肤科分会

收稿日期:2025-02-05 修回日期:2025-09-28 发布日期:2026-02-03
通讯作者: 李邻峰；温海 E-mail:zoonli@sina.com；wenhaipfk@126.com

Expert consensus on rational application of moisturizers for atopic dermatitis （2026 edition）

Environmental and Occupational Skin Disease Research Group, Chinese Dermatovenerology Society of Integrative Medicine; Committee on Dermatology, Chinese Association of Geriatric Research; Committee on Drugs for Dermatology, China Association of Traditional Chinese Medicine; Dermatology Branch of China Association for Promotion of Health Science and Technology

Environmental and Occupational Skin Disease Research Group, Chinese Dermatovenerology Society of Integrative Medicine; Committee on Dermatology, Chinese Association of Geriatric Research; Committee on Drugs for Dermatology, China Association of Traditional Chinese Medicine; Dermatology Branch of China Association for Promotion of Health Science and Technology

Received:2025-02-05 Revised:2025-09-28 Published:2026-02-03
Contact: Li Linfeng; Wen Hai E-mail:zoonli@sina.com；wenhaipfk@126.com

摘要/Abstract

摘要： 【摘要】保湿治疗是特应性皮炎重要基础治疗之一，虽然应用广泛，但在临床应用中还存在很多问题。中国中西医结合学会皮肤性病专业委员会环境与职业性皮肤病学组等组织国内相关专家以国内外相关指南、共识和临床文献为基础，结合专家临床经验，对保湿剂在特应性皮炎管理中的必要性、作用、适应证、禁忌证、注意事项、选择原则、用法、用量和不良反应等问题进行讨论，制订保湿剂在特应性皮炎管理中的合理应用专家共识，旨为临床规范应用保湿剂提供指导。

关键词: 皮炎, 特应性, 保湿剂, 润肤剂, 应用, 管理, 共识

Abstract: 【Abstract】 Moisturizer therapy is one of the fundamental treatments for atopic dermatitis. However, many challenges still exist in clinical practice despite its wide application. Based on Chinese and international guidelines, consensus, and clinical literature, and combined with expert clinical experience, an expert consensus on the rational use of moisturizers for atopic dermatitis was developed by a panel of Chinese experts convened by the Environmental and Occupational Skin Disease Research Group, Chinese Dermatovenerology Society of Integrative Medicine and other academic institutions. This consensus addresses key issues regarding the use of moisturizers in the management of atopic dermatitis, including the necessity of use, mechanisms of action, indications, contraindications, considerations during the application, selection principles, usage, dosage, and adverse reactions, aiming to provide guidance for the standardized application of moisturizers in clinical practice.

Key words: Dermatitis, atopic, Moisturizer, Emollient, Application, Management, Consensus

中国中西医结合学会皮肤性病专业委员会环境与职业性皮肤病学组中国老年保健医学研究会皮肤科分会中国中药协会皮肤病药物研究专业委员会中国人体健康科技促进会皮肤科分会. 保湿剂在特应性皮炎管理中的合理应用专家共识（2026版）[J]. 中华皮肤科杂志, 2026,59(2):107-112. doi:10.35541/cjd.20250050

Environmental and Occupational Skin Disease Research Group, Chinese Dermatovenerology Society of Integrative Medicine, Committee on Dermatology, Chinese Association of Geriatric Research, Committee on Drugs for Dermatology, China Association of Traditional Chinese Medicine, Dermatology Branch of China Association for Promotion of Health Science and Technology. Expert consensus on rational application of moisturizers for atopic dermatitis （2026 edition）[J]. Chinese Journal of Dermatology, 2026, 59(2): 107-112.doi:10.35541/cjd.20250050

参考文献 47

［1］	中国医师协会皮肤科医师分会. 保湿润肤类产品应用指导专家共识（2023版）［J］. 中华皮肤科杂志, 2023,56（8）:711⁃717. DOI: 10.35541/cjd.20230133.
［2］	中华医学会皮肤性病学分会儿童学组, 中国医师协会皮肤科医师分会儿童皮肤病专业委员会. 功效性护肤品在儿童特应性皮炎中的应用指南［J］. 中国皮肤性病学杂志, 2020,34（9）:977⁃981. DOI: 10.13735/j.cjdv.1001⁃7089.202006019.
［3］	Ortiz de Frutos FJ, Silvestre JF, （GEIDAC） rtSRGoCDaCA. Recommendations on the use of moisturizing products prepared by Spanish Dermatologists Using the Delphi Method［J］. Actas Dermosifiliogr, 2025,116（3）:T225⁃T232. DOI: 10.1016/j.ad.2024.12.004.
［4］	Wollenberg A, Barbarot S, Bieber T, et al. Consensus⁃based European guidelines for treatment of atopic eczema （atopic dermatitis） in adults and children: partⅠ［J］. J Eur Acad Dermatol Venereol, 2018,32（5）:657⁃682. DOI: 10.1111/jdv. 14891.
［5］	中华医学会皮肤性病学分会免疫学组, 特应性皮炎协作研究中心. 中国特应性皮炎诊疗指南（2020版）［J］. 中华皮肤科杂志, 2020,53（2）:81⁃88. DOI: 10.35541/cjd.20191000.
［6］	Phillips B, Ball C, Sackett D, et al. Oxford Centre for Evidence⁃Based Medicine: levels of evidence （March 2009）［EB/OL］.［2025⁃09⁃28］. https://www. cebm. ox. ac. uk/resources/levels⁃ofevidence/oxford⁃centre⁃for⁃evidence⁃based⁃medicine⁃levels⁃ofevidence⁃march⁃2009.
［7］	李妍, 李邻峰. 特应性皮炎的诊断与治疗［M］. 北京: 北京大学医学出版社, 2023:25.
［8］	Beck LA, Cork MJ, Amagai M, et al. Type 2 inflammation contributes to skin barrier dysfunction in atopic dermatitis［J］. JID Innov, 2022,2（5）:100131. DOI: 10.1016/j.xjidi.2022.100131.
［9］	Zhou L, Zhang G, Zhang K, et al. The role of PAR2 in regulating MIF release in house dust mite⁃induced atopic dermatitis［J］. Front Immunol, 2024,15:1478292. DOI: 10.3389/fimmu.2024. 1478292.
［10］	Hoyer A, Rehbinder EM, Färdig M, et al. Filaggrin mutations in relation to skin barrier and atopic dermatitis in early infancy［J］. Br J Dermatol, 2022,186（3）:544⁃552. DOI: 10.1111/bjd.20831.
［11］	Purnamawati S, Indrastuti N, Danarti R, et al. The role of moisturizers in addressing various kinds of dermatitis: a review［J］. Clin Med Res, 2017,15（3⁃4）:75⁃87. DOI: 10.3121/cmr. 2017.1363.
［12］	Koppes SA, Charles F, Lammers L, et al. Efficacy of a cream containing ceramides and magnesium in the treatment of mild to moderate atopic dermatitis: a randomized, double⁃blind, emollient⁃ and hydrocortisone⁃controlled trial［J］. Acta Derm Venereol, 2016,96（7）:948⁃953. DOI: 10.2340/00015555⁃2395.
［13］	申春平, 刘晓雁, 王榴慧, 等. 类人胶原蛋白修复敷料辅助治疗儿童特应性皮炎的临床研究［J］. 实用皮肤病学杂志, 2023,16（4）:193⁃196,205. DOI: 10.11786/sypfbxzz.1674⁃1293.20230401.
［14］	尤艺璇, 涂颖, 刘海洋, 等. 青刺果油对特应性皮炎样小鼠模型表皮通透屏障及抗菌肽表达的影响［J］. 中国皮肤性病学杂志, 2018,32（6）:632⁃637. DOI: 10.13735/j.cjdv.1001⁃7089. 201709101.
［15］	Zheng BW, Wang BY, Xiao WL, et al. Different molecular weight hyaluronic acid alleviates inflammation response in DNFB⁃induced mice atopic dermatitis and LPS⁃induced RAW 264.7 cells［J］. Life Sci, 2022,301:120591. DOI: 10.1016/j.lfs. 2022.120591.
［16］	Marini A, Reinelt K, Krutmann J, et al. Ectoine⁃containing cream in the treatment of mild to moderate atopic dermatitis: a randomised, comparator⁃controlled, intra⁃individual double⁃blind, multi⁃center trial［J］. Skin Pharmacol Physiol, 2014,27（2）:57⁃65. DOI: 10.1159/000351381.
［17］	Lisante TA, Kizoulis M, Nuñez C, et al. A 1% colloidal oatmeal OTC cream is clinically effective for the management of mild to moderate atopic dermatitis in Black or African American children［J］. J Dermatolog Treat, 2023,34（1）:2241587. DOI: 10.1080/09546634.2023.2241587.
［18］	窦丽敏, 吴瑶, 宋玮, 等. 含马齿苋等提取物的润肤剂改善（2～12）岁儿童缓解期特应性皮炎严重性的多中心、随机、平行对照临床研究［J］. 皮肤病与性病, 2020,42（5）:648⁃651. DOI: 10.3969/j.issn.1002⁃1310.2020.05.009.
［19］	Panahi Y, Rastgar N, Zamani A, et al. Comparing the therapeutic effects of Aloe vera and olive oil combination cream versus topical betamethasone for atopic dermatitis: a randomized double⁃blind clinical trial［J］. J Pharmacopuncture, 2020,23（3）:173⁃178. DOI: 10.3831/KPI.2020.23.3.173.
［20］	Champer J, Patel J, Fernando N, et al. Chitosan against cutaneous pathogens［J］. AMB Express, 2013,3（1）:37. DOI: 10. 1186/2191⁃0855⁃3⁃37.
［21］	Zhou Y, Xu X, Liu Y, et al. Heterogeneous regulation of Staphylococcus Aureus by different Staphylococcus Epidermidis agr types in atopic dermatitis［J］. J Invest Dermatol, 2023,143（12）:2484⁃2493. DOI: 10.1016/j.jid.2023.05.014.
［22］	Onwuliri V, Agbakoba NR, Anukam KC. Topical cream containing live lactobacilli decreases malodor⁃producing bacteria and downregulates genes encoding PLP⁃dependent enzymes on the axillary skin microbiome of healthy adult Nigerians［J］. J Cosmet Dermatol, 2021,20（9）:2989⁃2998. DOI: 10.1111/jocd. 13949.
［23］	Seité S, Zelenkova H, Martin R. Clinical efficacy of emollients in atopic dermatitis patients ⁃ relationship with the skin microbiota modification［J］. Clin Cosmet Investig Dermatol, 2017,10:25⁃33. DOI: 10.2147/CCID.S121910.
［24］	Bzioueche H, Tamelghaghet M, Chignon⁃Sicard B, et al. Ceramide AD™ restores skin integrity and function following exposure to house dust mite［J］. Int J Mol Sci, 2023,24（11）:9234. DOI: 10.3390/ijms24119234.
［25］	Andrew PV, Pinnock A, Poyner A, et al. Maintenance of an acidic skin surface with a novel zinc lactobionate emollient preparation improves skin barrier function in patients with atopic dermatitis［J］. Dermatol Ther （Heidelb）, 2024,14（2）:391⁃408. DOI: 10.1007/s13555⁃023⁃01084⁃x.
［26］	Bradshaw LE, Wyatt LA, Brown SJ, et al. Emollients for prevention of atopic dermatitis: 5⁃year findings from the BEEP randomized trial［J］. Allergy, 2023,78（4）:995⁃1006. DOI: 10. 1111/all.15555.
［27］	Simpson EL, Michaels LC, Ramsey K, et al. Emollients to prevent pediatric eczema: a randomized clinical trial［J］. JAMA Dermatol, 2025,161（9）:957⁃965. DOI: 10.1001/jamadermatol. 2025.2357.
［28］	Ridd MJ, Wells S, MacNeill SJ, et al. Comparison of lotions, creams, gels and ointments for the treatment of childhood eczema: the BEE RCT［J］. Health Technol Assess, 2023,27（19）:1⁃120. DOI: 10.3310/GZQW6681.
［29］	Danby SG, Andrew PV, Taylor RN, et al. Different types of emollient cream exhibit diverse physiological effects on the skin barrier in adults with atopic dermatitis［J］. Clin Exp Dermatol, 2022,47（6）:1154⁃1164. DOI: 10.1111/ced.15141.
［30］	Bradshaw LE, Wyatt LA, Brown SJ, et al. Emollient application from birth to prevent eczema in high⁃risk children: the BEEP RCT［J］. Health Technol Assess, 2024,28（29）:1⁃116. DOI: 10.3310/RHDN9613.
［31］	Hamann CR, Hamann D, Egeberg A, et al. Association between atopic dermatitis and contact sensitization: a systematic review and meta⁃analysis［J］. J Am Acad Dermatol, 2017,77（1）:70⁃78. DOI: 10.1016/j.jaad.2017.02.001.
［32］	Bonamonte D, Hansel K, Romita P, et al. Contact allergy in children with and without atopic dermatitis: an Italian multicentre study［J］. Contact Dermatitis, 2022,87（3）:265⁃272. DOI: 10.1111/cod.14130.
［33］	Gupta S, Ramam M, Sharma VK, et al. Evaluation of a paraffin⁃based moisturizer compared to a ceramide⁃based moisturizer in children with atopic dermatitis: a double⁃blind, randomized controlled trial［J］. Pediatr Dermatol, 2023,40（4）:627⁃632. DOI: 10.1111/pde.15355.
［34］	Rigal A, Michael⁃Jubeli R, Bigouret A, et al. Skin surface lipid composition in women: increased 2,3⁃oxidosqualene correlates with older age［J］. Eur J Dermatol. 2020,30（2）:103⁃110. DOI: 10.1684/ejd.2020.3753.
［35］	Gallagher A, Hourihane JO, Kenny LC, et al. A longitudinal study of skin barrier function in pregnancy and the postnatal period［J］. Obstet Med, 2014,7（4）:156⁃159. DOI: 10.1177/1753495X14547428.
［36］	Yang M, Zhou M, Li Y, et al. Lipidomic analysis of facial skin surface lipid reveals the causes of pregnancy⁃related skin barrier weakness［J］. Sci Rep, 2021,11（1）:3229. DOI: 10.1038/s41598⁃021⁃82624⁃3.
［37］	Wollenberg A, Kinberger M, Arents B, et al. European guideline （EuroGuiDerm） on atopic eczema ⁃ partⅡ: non⁃systemic treatments and treatment recommendations for special AE patient populations［J］. J Eur Acad Dermatol Venereol, 2022,36（11）:1904⁃1926. DOI: 10.1111/jdv.18429.
［38］	李玲艳, 席建元, 郝静, 等. 止痒润肤乳联合糠酸莫米松软膏对成人期特应性皮炎（血虚风燥型）临床观察［J］. 中医药临床杂志, 2020,32（10）:1965⁃1968. DOI: 10.16448/j.cjtcm.2020.1044.
［39］	陈俊钊, 黄文富, 李庆祥, 等. 卤米松乳膏联合尿素软膏治疗手部慢性湿疹效果观察［J］. 临床合理用药杂志, 2012,5（5）:67⁃68. DOI: 10.3969/j.issn.1674⁃3296.2012.05.055.
［40］	Ng SY, Begum S, Chong SY. Does order of application of emollient and topical corticosteroids make a difference in the severity of atopic eczema in children?［J］. Pediatr Dermatol, 2016,33（2）:160⁃164. DOI: 10.1111/pde.12758.
［41］	中国医师协会皮肤科医师分会, 中华医学会皮肤性病学分会, 中国医疗保健国际交流促进会皮肤医学分会, 等. 特应性皮炎治疗药物应用管理专家共识（2024版）［J］. 中华皮肤科杂志, 2024,57（2）:97⁃108. DOI: 10.35541/cjd.20230358.
［42］	Surber C, Robertis J, Reinau D. Topical corticosteroid or emollient product: which to apply first?［J］. J Eur Acad Dermatol Venereol, 2023,37（5）:e646⁃e647. DOI: 10.1111/jdv.18797.
［43］	van Zuuren EJ, Fedorowicz Z, Christensen R, et al. Emollients and moisturisers for eczema［J］. Cochrane Database Syst Rev, 2017,2（2）:CD012119. DOI: 10.1002/14651858.CD012119.pub2.
［44］	Danby SG, Andrew PV, Taylor RN, et al. Different types of emollient cream exhibit diverse physiological effects on the skin barrier in adults with atopic dermatitis［J］. Clin Exp Dermatol, 2022,47（6）:1154⁃1164. DOI: 10.1111/ced.15141.
［45］	Goh SW, Jamil A, Safian N, et al. A randomized half⁃body, double blind, controlled trial on the effects of a pH⁃modified moisturizer vs. standard moisturizer in mild to moderate atopic dermatitis［J］. An Bras Dermatol, 2020,95（3）:320⁃325. DOI: 10.1016/j.abd.2019.11.007.
［46］	Grześk⁃Kaczyńska M, Petrus⁃Halicka J, Kaczyński S, et al. Should emollients be recommended for the prevention of atopic dermatitis? ⁃ new evidence and current state of knowledge［J］. J Clin Med, 2024,13（3）:863. DOI: 10.3390/jcm13030863.
［47］	李邻峰, 李妍. 接触性皮炎的诊断与治疗［M］. 北京: 北京大学医学出版社, 2023:142.

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[15]	中国儿童鲜红斑痣诊断和治疗专家共识制订专家组中国医师协会皮肤科医师分会儿童学组. [开放获取] 儿童鲜红斑痣诊疗专家共识（2025版）[J]. 中华皮肤科杂志, 2025, 58(5): 396-404.

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