黄褐斑发病机制与临床对策的新认识

doi:10.35541/cjd.20250004

中华皮肤科杂志 ›› 2025, Vol. 58 ›› Issue (9): 797-800.doi: 10.35541/cjd.20250004

• 专家论坛·色素性皮肤病 • 上一篇下一篇

黄褐斑发病机制与临床对策的新认识

张成锋,金尚霖

复旦大学附属华山医院皮肤科，上海 200040

收稿日期:2025-01-06 修回日期:2025-03-15 发布日期:2025-09-01
通讯作者: 张成锋 E-mail:e3dangdang@hotmail.com
基金资助:
国家自然科学基金（82173421、82473523）；国家重点研发计划（2023YFC2509001）；上海市重中之重研究中心建设项目（2023ZZ02018）；上海申康医院发展中心项目（SHDC22022302）

New insights into the pathogenesis and clinical therapeutic strategies of melasma

Zhang Chengfeng, Jin Shanglin

Department of Dermatology, Huashan Hospital, Fudan University, Shanghai 200040, China

Received:2025-01-06 Revised:2025-03-15 Published:2025-09-01
Contact: Zhang Chengfeng E-mail:e3dangdang@hotmail.com
Supported by:
National Natural Science Foundation of China （82173421, 82473523）; National Key Research and Development Program of China （2023YFC2509001）; Shanghai Key and Major Research Center Construction Project （2023ZZ02018）; Shanghai Hospital Development Center Project （SHDC22022302）

摘要/Abstract

摘要： 【摘要】黄褐斑的病因和发病机制尚未完全明了。本文回顾近年来黄褐斑的研究进展，探讨光老化、皮肤屏障功能受损、肥大细胞激活、性激素波动及昼夜节律紊乱等在黄褐斑发病中的作用，为黄褐斑的临床防治提供新方向。随着对黄褐斑发病机制的深入理解，未来的治疗策略有望从单纯的色素沉着治疗转向综合性的抗光老化治疗和皮肤修复。

关键词: 黑变病, 皮肤衰老, 性腺激素类, 昼夜节律, 黄褐斑, 光老化, 皮肤屏障

Abstract: 【Abstract】 The etiology and pathogenesis of melasma have not been fully elucidated. This article summarizes the recent research progress on melasma, explores the roles of photoaging, skin barrier dysfunction, mast cell activation, sex hormone fluctuations, and circadian rhythm disturbances in its pathogenesis, with the aim of providing new directions for its clinical prevention and treatment. With a deeper understanding of the pathogenesis of melasma, future therapeutic strategies are expected to shift from solely addressing skin pigmentation to comprehensive approaches involving anti-photoaging therapies and skin repair interventions.

Key words: Melanosis, Skin aging, Gonadal hormones, Circadian rhythm, Melasma, Photoaging, Skin barrier

张成锋金尚霖. 黄褐斑发病机制与临床对策的新认识[J]. 中华皮肤科杂志, 2025,58(9):797-800. doi:10.35541/cjd.20250004

Zhang Chengfeng, Jin Shanglin. New insights into the pathogenesis and clinical therapeutic strategies of melasma[J]. Chinese Journal of Dermatology, 2025, 58(9): 797-800.doi:10.35541/cjd.20250004

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黄褐斑发病机制与临床对策的新认识

New insights into the pathogenesis and clinical therapeutic strategies of melasma

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