中华皮肤科杂志 ›› 2024, Vol. 57 ›› Issue (10): 887-890.doi: 10.35541/cjd.20240264

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大疱性类天疱疮的治疗难点与对策

王刚   

  1. 空军军医大学西京皮肤医院,西安  710032
  • 收稿日期:2024-05-16 修回日期:2024-07-16 发布日期:2024-09-29
  • 通讯作者: 王刚 E-mail:xjwgang@fmmu.edu.cn
  • 基金资助:
    国家自然科学基金(82173410);陕西省重点研发计划项目(2022ZDLSF03-14)

Challenges and strategies for the treatment of bullous pemphigoid

WANG Gang   

  1. Department of Dermatology, Xijing Hospital, Air Force Medical University, Xi′an 710032, China
  • Received:2024-05-16 Revised:2024-07-16 Published:2024-09-29
  • Contact: Wang Gang E-mail:xjwgang@fmmu.edu.cn
  • Supported by:
    National Natural Science Foundation of China(82173410); Key Research and Development Program of Shaanxi Province (2022ZDLSF03-14)

摘要: 【摘要】 大疱性类天疱疮是临床常见的自身免疫性大疱病,糖皮质激素外用或系统应用是其一线治疗选择,多数患者治疗反应良好,经过一定时间的维持巩固可以达到治愈目标。尽管如此,大疱性类天疱疮治疗中也存在一些难点,如病情严重难以控制、对治疗抵抗、治疗后复发、合并复杂共病或合并症等,构成临床挑战。在合理、科学、安全地用好糖皮质激素的基础上,根据患者的具体情况进行充分的分析和评估,通过调整糖皮质激素剂量,单独或联合使用免疫调节剂、免疫抑制剂、生物制剂、小分子靶向药物等方法,可以有效地化解治疗难题,使患者的病情得到稳定控制。

关键词: 类天疱疮, 大疱性, 治疗, 糖皮质激素, 免疫抑制剂, 生物制剂, 小分子靶向药物

Abstract: 【Abstract】 Bullous pemphigoid (BP) is the most common autoimmune bullous disease in clinical practice. Topical or systemic glucocorticoids are the first-line treatment for BP, and most patients respond well to glucocorticoids and can achieve the goal of healing after consolidation and maintenance treatments. However, there are some difficulties in the treatment of BP, such as severe and uncontrolled BP, recalcitrant BP, relapsing BP, and the presence of complex comorbidities or complications, which pose clinical challenges. Based on the rational, scientific and safe use of glucocorticoids, as well as the analysis and evaluation of each patient′s specific condition, optimizing the glucocorticoid dosage and using glucocorticoids alone or in combination with immunomodulators, immunosuppressants, biological agents, and small-molecule targeted drugs may effectively help resolve the difficulties in BP treatment and stabilize patients′ condition.

Key words: Pemphigoid, bullous, Therapy, Glucocorticoids, Immunosuppressive agents, Biologics, Small-molecule targeted drugs

引用本文

王刚. 大疱性类天疱疮的治疗难点与对策[J]. 中华皮肤科杂志, 2024,57(10):887-890. doi:10.35541/cjd.20240264

Wang Gang. Challenges and strategies for the treatment of bullous pemphigoid[J]. Chinese Journal of Dermatology, 2024, 57(10): 887-890.doi:10.35541/cjd.20240264