关键词: 淋巴瘤，T细胞, CD8阳性T淋巴细胞, 病例报告［文献类型］

Abstract: Dong Zhengbang*, Zhang Lihua, Zhang Jingdong, Pan Yongzheng, Zhao Deming, Wang Fei. *Department of Dermatology and Venereology, Zhongda Hospital, Southeast University, Nanjing 210009, China Corresponding author: Wang Fei, Email: ffwangfei@163.com 【Abstract】 A 44-year-old female presented with ulcers and plaques on the trunk for two months. The lesions began as red plaques, and rapidly developed into ulcers. Histopathology revealed an infiltrate of middle to large atypical lymphoid cells throughout the dermis and subcutaneous fat layer along with epidermotropism. Immunohistochemically, the atypical cells showed positive staining for CD3, CD8, CD56, granzyme B, perforin, but negative staining for the α/β chain of T cell receptor, CD4, CD5, CD20 and CD79α. Epstein-Barr virus-encoded RNA （EBER） was undetected. PCR confirmed the rearrangement of TCR-γ gene. According to the above findings, a diagnosis of cutaneous γ/δ T-cell lymphoma was made. The patient gave up therapy, and died 20 months after the onset of disease.

Key words: Lymphoma, T-cell, CD8-positive T-lymphocytes, Case reports ［Publication types］