中华皮肤科杂志 ›› 1991, Vol. 24 ›› Issue (6): 383-385.

• 论著 • 上一篇    下一篇

正常人和硬皮病患者皮肤中Ⅲ型胶原和板层粘连蛋白的分布及其意义

廖文俊, 魏克庄, 车乃增, 王伯云   

  1. 第四军医大学第一附属医院皮肤科, 西安 710032
  • 收稿日期:1990-07-24 修回日期:1990-12-03 出版日期:1991-12-15 发布日期:1991-12-15

Distribution and Significance of Type Ⅲ Collagen amd Lamimixa in Normal and Scleroderma Skin

LIAO Wen-Jun, CHE Nai-Zheng   

  1. The First Affiliated Hospital Fourth Military Medical University, Xi-an
  • Received:1990-07-24 Revised:1990-12-03 Online:1991-12-15 Published:1991-12-15

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摘要： 对Ⅲ型胶原和板层粘连蛋白(LN)进行免疫组化研究发现,正常人皮肤中Ⅲ型胶原主要分布在真皮乳头部和血管、附属器周围,而硬皮病皮肤中Ⅲ型胶原则大量沉积于整个真皮,正常人皮肤中LN呈线状分布于真皮各处的基底膜带,而硬皮病皮肤的真表皮交界处LN则呈节段性增粗,有些部位LN消失.

关键词: 疱疹，生殖器, NK细胞, 受体, 共刺激分子

Abstract: Immunohistochemical technique was used to detect type Ⅲ collagen and laminin in normal and scleroderma skin.Distribution oftype Ⅲ collagen in the normal skin was predominantly present at the dermal papillae and around epidermal appendages and blood vessels,but in scleroderma skin,a great quantity of type Ⅲ collagen was dcpositcrl in the whole detmis.Laminin at the derrno-epidermal junction in sclcroderma skin was partially coarser,or disappeared in some areas this was different from that in normal skin where the laminin showed continuous linear staining pattern.