中华皮肤科杂志 ›› 1989, Vol. 22 ›› Issue (2): 75-77.

• 论著 •    下一篇

SLE患者血浆血栓素BZ和6-K-PGF1α的变化

施燕, 徐文严, 靳培英, 岳晓玉   

  1. 中国医学科学院皮肤病研究所
  • 收稿日期:1987-11-05 修回日期:1988-05-25 出版日期:1989-04-15 发布日期:1989-04-15

THROMBOXANE B2 AND 6-KETO-PROSTAGLANDIN F1α IN SLE

SHI Yan, XU Wen-Yan   

  1. Institute of Dennatology, Chinese academy of Medical Sciences, Nanjing
  • Received:1987-11-05 Revised:1988-05-25 Online:1989-04-15 Published:1989-04-15

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摘要： 本文报告50例SLE患者和38例正常人血浆血栓素B2(TXB2)和6-酮-前列腺素F1α(6-K-PGF1α)检铡水平.测定结果,SLE各组血浆6-K-PGF1α值比正常组低,差异非常显著.SLE各组、活动组血浆TXB2值高于正常组、SLE轻型组及稳定组,差异均非常显著.SLE名组6-K-PGF1α/TXB2值均低于正常组,且随病情的轻重而升降.表明检测血浆TXB2,6-K-PGF1α有助于估价SLE疾病的疗效和预后.

Abstract: Plasma TXB2 and 6-K-PGF1α were measured by radioimmunoassay in 50 patients wish SLE and 38 healthy persons.The result showed that the 6-K-PGFIa levels of SLE patients were lower than those of controls.The TXB2 values of severe group (SG) and active group (AG) were significantly increased when compered with those of mild group (MG),stable group (STG) and control group (CG).The K/T (6-K-PGF1α/TXB2) ratios of all SLE groups < CG.The K/T ratio correlates with the severity of the disease.The results suggest that the determination of both TXB2 and 6-K-PGF1α is helpful for the evaluation of the therapeutic effect and prognosis in SLE patients.