中华皮肤科杂志

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干细胞因子及其受体在寻常型白癜风表皮中的表达

王克玉1, 李春阳1, 冯进波2   

  1. 1. 山东大学齐鲁医院皮肤科, 济南250012;
    2. 山东大学齐鲁医院心血管实验室, 济南250012
  • 收稿日期:2006-01-12 出版日期:2006-04-15 发布日期:2006-04-15
  • 通讯作者: 李春阳,email:jnlicy@jnnc.com E-mail:jnlicy@jnnc.com

The expression of stem cell factor and its receptor in epidermis of vitiligo vulgaris

WANG Ke-yu1, LI Chun-yang1, FENG Jin-bo2   

  1. Department of Dermatology, Qilu Hospital of Shandong University, Jinan 250012, China
  • Received:2006-01-12 Online:2006-04-15 Published:2006-04-15

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摘要： 目的 探讨SCF/c-kit信号通路在白癜风发病中的作用。方法 采用免疫组化和RT-PCR法检测17例寻常型稳定期白癜风患者和10例正常对照标本中表皮角质形成细胞的干细胞因子表达及基底层黑素细胞c-kit的表达情况。结果 白癜风非皮损区干细胞因子、c-kit蛋白表达与正常对照无明显差异(P>0.05),皮损区干细胞因子表达显著高于正常对照皮肤(P<0.05),而c-kit表达显著低于正常对照皮肤(P<0.05)。白癜风非皮损区表皮干细胞因子、c-kit mRNA表达平均水平与正常对照近似(P>0.05);皮损区干细胞因子mRNA表达水平高于非皮损区及正常对照组差异有统计学意义(P<0.05);皮损区c-kit mRNA表达水平显著低于非皮损区及正常对照组(P<0.05)。结论 SCF/c-kit的异常表达可能与白癜风的发病有关。

关键词: 白癜风, 角蛋白细胞, 黑素细胞, 干细胞因子, 原癌基因蛋白质c-kit

Abstract: Objective To study the role of stem cell factor (SCF)/c-kit pathway in the pathogenesis of vitiligo,Methods The expression of SCF and c-kit was detected by immunohistochernistry and RT-PCR in 17 patients with stable vitiligo vulgaris and 10 healthy controls.Results The protein expression of SCF and c-kit was of no difference between the non-lesional epidermis of vitiligo and the control skin (P>0.05).A significantly higher protein expression of SCF and lower protein expression of c-kit were detected in lesional epidermis of vitiligo compared with the control skin (both P<0.05),The mRNA expression of SCF and c-kit was similar between non-lesional epidermis of vitiligo and control skin (P>0.05),while the level of SCF mRNA was significantly higher in lesional epidermis of vitiligo than that in non-lesional epidermis of vitiligo and control skin (P<0.05).The level of c-kit mRNA was markedly decreased in lesional epidermis than in non-lesional epidermis and control skin(P<0.05).Conclusion The abnormal expression of SCF and c-kit may be related to the pathogenesis of vitiligo.

Key words: Vitiligo, keratinocytes, Melanocytes, Stem cell factor, Proto-oncogene protein c-kit