中华皮肤科杂志 ›› 1990, Vol. 23 ›› Issue (5): 305-307.

• 论著 • 上一篇    下一篇

7,12一二甲基苯蒽对Thy-1+树突状表皮细胞和郎格罕细胞的影响及其与肿瘤发生的关系

曾理, 陈洪铎   

  1. 中国医科大学附属第一医院皮肤科
  • 收稿日期:1989-01-25 修回日期:1989-05-17 发布日期:1990-10-15
  • 基金资助:
    国家自然科学基金课题

Effect of 7, 12-dimethylbcuzanthracene on Thy-1 positive deaidritic epidermal cells, Langerhans cells and their relationship to tumor formation

ZHEN Li, CHEN Hong-Duo   

  1. The First Hospital, China Medical University, Shenyang
  • Received:1989-01-25 Revised:1989-05-17 Published:1990-10-15

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摘要： 正常小鼠表皮内有两种来源于骨髓和(或)脾脏的树突状表皮细胞、即Thy-1+树突状表皮细胞(Thy-1+dEC)和郎格罕细胞(LC).7.12-二甲基苯惠(7.12-Dimethyl benzan thracene,DMBA)是一种强化学致癌剂,每周一次涂抹于小鼠皮肤可诱发肿瘤.经抗小鼠Thy-1+和Ia抗原的单克隆抗体的间接免疫荧光和免疫荧光双标记法,我们证实(劝雄性小鼠表皮内Thy-1+dEC及LC密度分别低于雌性,(2)DMBA诱发肿瘤的机制可能与Thy-1+dEC和LC密度的动态变化有关.

Abstract: In murine skin there are two kinds of dendritie cells which, are derived from bone marrow and/or spleen, i.e. Thy-1 positive dendritic epidermal cells (Tliy-1+dEC) and Langerhans cells (LC). 7.12-Dimetyllbenzanthracene (DMBA) is a potent chemieal carcinogen which, when applied weekly to the mouse skin,causes the inductioa of skin tumors.