中华皮肤科杂志 ›› 1989, Vol. 22 ›› Issue (5): 294-295.

• 论著 • 上一篇    下一篇

带状疱疹患者细胞免疫功能测定

高庆林1, 熊声忠1, 郭实士2   

  1. 1. 湖南医科大学
  • 收稿日期:1988-03-28 修回日期:1988-09-01 出版日期:1989-10-15 发布日期:1989-10-15
  • 基金资助:
    国家自然科学基金资助

Observation of cellular immunity in herpes zoster patients

GAO Qing-Lin1, XIONG Sheng-Zhong1   

  1. The First Affiliated Hospital, Hunan Medical University, Changsha
  • Received:1988-03-28 Revised:1988-09-01 Online:1989-10-15 Published:1989-10-15

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摘要： 本文测定了34例急性期带状疱疹(HZ)患者和30例健康人外周血单一核细胞(PBMC)产生白细胞介素2(IL-2)的能力及自然杀伤(NK)活性,并对11例HZ患者急性期与恢复期IL-2的活性进行了比较.结果发现HZ患者急性期PBMC产生IL-2的能力较对照组明显降低(P<0.01).而NK活性和正常人比较无显著差异(P>0.05).11例患者急性期与恢复期IL-2活性比较,恢复期高于急性期,但无统计学意义(P>0.05).作者就其结果进行了讨性,认为IL-2在HZ的发病中可能起一定的作用.推测用纯化的IL-2或提高体内IL-2的产生可能对HZ的治疗有益.

Abstract: In this paper, the results of IL-2 production and NK activity of peripheral blood mononuclear cells (PBMC) from 34 patients with herpes zoster (HZ) and 30 normal donors and the observation of IL-2 level between acute and recovery phase from 11 patients with HZ are reported. The results indicated that IL-2 level of PBMC from patients with HZ decreased significantly when compared to normal donors (P<0.01). By contrast, there was no difference between the patients and healthy group in NK activity (P>0.05), and the difference of IL-2 level between acute and recovery phase of 11 patients with HZ was not significant (P>0.05). According to these results, the authors suggest that the diminished IL-2 production may play a role in the development of HZ, and postulate that it is of benefit to treat HZ by using exogeneous IL-2 or raising IL-2 production in vivo.