中华皮肤科杂志 ›› 1988, Vol. 21 ›› Issue (6): 345-347.

• 论著 • 上一篇    下一篇

银屑病患者血清抗角蛋白抗体的免疫荧光研究

刘玉峰1, 车乃增1, 张泰山1, 祝连庆1, 刘彦仿2, 丁华野2   

  1. 1. 第四军医大学西京医院皮肤科;
    2. 第四军医大学病理解剖学教研室
  • 收稿日期:1987-06-30 修回日期:1987-08-25 出版日期:1989-02-15 发布日期:1989-02-15

Observation on anti-keratin antibody in patients with psoriasis

LIU Yu-Feng1, CHE Nai-Zeng1   

  1. Xi-jinng Hospital, The Fourth Military Medical College, Xi'an
  • Received:1987-06-30 Revised:1987-08-25 Online:1989-02-15 Published:1989-02-15

摘要: 为了探讨血清抗角蛋白抗体与银屑病的关系以及该抗体的生理、病理意义,本文以正常人皮肤冰冻切片为抗原,用IIF检测了35例银屑病患者的血清,并与其它皮肤病和内科疾患作了对照观察.银屑病患者血清抗角蛋白抗体阳性率IgG11.76%,IgM54.29%,IgA54.29%,与正常人(IgG66,67%,IgM96.43%,IgA100%)相比,均明显降低.但23例其它皮肤病IgM60.85%,IgA43%和25例内科疾患IgM63.38%也明显低于正常人.结果提示,抗角蛋白抗体血清阳性率的降低,并非银屑病的特异表现,两者之间并无特殊联系.

Abstract: In order to investigate the relationship between anti-keratin antibody and psoriasis, and the physiologic and pathologic roles of the antibody,35 sera from patients with psoriasis were studied by indirect immunofluorescence with normal skin cryosection as asubstrate.