光动力治疗中疼痛管理研究进展

摘要/Abstract

摘要：

局部光动力疗法是一种高效、安全、无创的治疗方法，对于皮肤科领域的多种疾病具有良好的疗效，如，光线性角化病、尖锐湿疣、痤疮等。制约光动力疗法普及的主要原因是在治疗过程中产生的疼痛，有些患者因无法耐受需要暂停甚至终止治疗。目前，对于PDT疼痛的控制研究已经取得了一些进展。影响PDT疼痛的因素有个体特征、皮损特征和治疗参数如光源、光敏剂等。用于控制PDT疼痛的方法有局部降温、口服镇痛药、二步照射法、表面麻醉、注射麻醉、吸入性麻醉、经皮神经电刺激、催眠等。

Abstract:

Li Mingjing, Cao Jingjiang, Chen Hongxiang Department of Dermatology, The Second College of Clinical Medical Science, Three Gorges University, Yichang 443002, China （Li MJ, Cao JJ）; Department of Dermatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China （Chen HX） Corresponding author: Chen Hongxiang, Email: hongxiangchen@hotmail.com 【Abstract】 Topical photodynamic therapy （PDT）, a highly effective, safe and non-invasive therapeutic method, exerts good therapeutic effects on various diseases in dermatology, such as actinic keratosis, condyloma acuminatum, acne，and so on. The major drawback of PDT is pain during the treatment. Some patients have to interrupt or terminate the treatment because of pain intolerance. Some progress has been made in the management of PDT-related pain. It has been revealed that multiple factors are associated with PDT-related pain, including individual factors, lesion characteristics, therapeutic parameters （such as light sources, photosensitizers）. Many methods can be used to manage PDT-related pain, including local cooling, oral analgesics, two-step irradiance protocol, topical anesthesia, injection anesthesia, inhalation anesthesia, transcutaneous electric nerve stimulation, hypnosis.

李明静曹经江陈宏翔. 光动力治疗中疼痛管理研究进展[J]. 中华皮肤科杂志, 2016, 49(9): 676-679.

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