[开放获取]    孢子丝菌病诊疗指南

中华皮肤科杂志 ›› 2016, Vol. 49 ›› Issue (7): 456-459.

[开放获取] 孢子丝菌病诊疗指南

中华医学会皮肤性病学分会真菌学组；中国医师协会皮肤科医师分会医学真菌亚专业委员会；中西医结合学会皮肤性病专业委员会真菌学组

中华医学会皮肤性病学分会真菌学组；中国医师协会皮肤科医师分会医学真菌亚专业委员会；中西医结合学会皮肤性病专业委员会真菌学组

收稿日期:2015-12-07 修回日期:2016-01-05 发布日期:2016-06-30
通讯作者: 李若瑜 E-mail:lrymm@medmail.com.cn

Guidelines for the diagnosis and treatment of sporotrichosis

Mycology Group of Chinese Society of Dermatology; Subcommittee on Medical Mycology, Chinese Dermatologist Association; Mycology Group, Committee on Dermatology and Venereology, China Society of Integrated Traditional Chinese and Western Medicine

Mycology Group of Chinese Society of Dermatology; Subcommittee on Medical Mycology, Chinese Dermatologist Association; Mycology Group, Committee on Dermatology and Venereology, China Society of Integrated Traditional Chinese and Western Medicine

Received:2015-12-07 Revised:2016-01-05 Published:2016-06-30

摘要/Abstract

摘要：

孢子丝菌病（sporotrichosis）是由申克孢子丝菌复合体（Sporothrix schenckii complex）感染皮肤、皮下组织、黏膜和局部淋巴系统所引起的慢性感染性疾病，偶可播散全身，引起多系统性损害。皮损主要表现为慢性炎症性肉芽肿损害，可形成丘疹、脓疱、结节、斑块、溃疡、肉芽肿、结痂等改变，常累及面部、四肢等暴露部位……

中图分类号:

R756.6

中华医学会皮肤性病学分会真菌学组, 中国医师协会皮肤科医师分会医学真菌亚专业委员会, 中西医结合学会皮肤性病专业委员会真菌学组. [开放获取] 孢子丝菌病诊疗指南[J]. 中华皮肤科杂志, 2016,49(7):456-459. doi:

Mycology Group of Chinese Society of Dermatology, Subcommittee on Medical Mycology, Chinese Dermatologist Association, Mycology Group, Committee on Dermatology and Venereology, China Society of Integrated Traditional Chinese and Western Medicine. Guidelines for the diagnosis and treatment of sporotrichosis[J]. Chinese Journal of Dermatology, 2016, 49(7): 456-459.doi:

参考文献 35

［1］	Lindsley MD, Hurst SF, Iqbal NJ, et al. Rapid identification of dimorphic and yeast⁃like fungal pathogens using specific DNA probes［J］. J Clin Microbiol, 2001, 39（10）: 3505⁃3511. DOI: 10.1128/JCM.39.10.3505⁃3511.2001.
［2］	Marimon R, Gené J, Cano J, et al. Molecular phylogeny of Sporothrix schenckii［J］. J Clin Microbiol, 2006, 44（9）: 3251⁃3256. DOI: 10.1128/JCM.00081⁃06.
［3］	Marimon R, Cano J, Gené J, et al. Sporothrix brasiliensis, S. globosa, and S. mexicana, three new Sporothrix species of clinical interest［J］. J Clin Microbiol, 2007, 45（10）: 3198⁃3206. DOI: 10.1128/JCM.00808⁃07.
［4］	Zhang Y, Hagen F, Stielow B, et al. Phylogeography and evolutionary patterns in Sporothrix spanning more than 14 000 human and animalcase reports［J］. Persoonia, 2015, 35: 1⁃20. DOI: 10.3767/003158515X687416.
［5］	Chakrabarti A, Bonifaz A, Gutierrez⁃Galhardo MC, et al. Global epidemiology of sporotrichosis［J］. Med Mycol, 2015, 53（1）: 3⁃14. DOI: 10.1093/mmy/myu062.
［6］	Oliveira MM, Almeida⁃Paes R, Muniz MM, et al. Phenotypic and molecular identification of Sporothrix isolates from an epidemic area of sporotrichosis in Brazil［J］. Mycopathologia, 2011, 172（4）: 257⁃267. DOI: 10.1007/s11046⁃011⁃9437⁃3.
［7］	景东云, 王学军, 彭琳琳, 等. 临床分离99 株孢子丝菌病原体的分子和表型鉴定［J］. 中国皮肤性病学杂志, 2015, 29（3）: 231⁃234. DOI: 10.13735/j. cjdv. 1001⁃7089. 201407136.
	Jing DY, Wang XJ, Peng LL, et al. Phenotypic and molecular identification of sporothrix 99 isolates of clinical origin［J］. Chin J Derm Venereol, 2015, 29（3）: 231⁃234. DOI: 10. 13735/j. cjdv. 1001⁃7089.201407136.
［8］	谭静文, 刘伟, 万喆, 等. 来自中国北方部分地区 33 株孢子丝菌菌株的表型和基因型鉴定［J］. 菌物学报, 2013, 32（2）: 161⁃167. DOI: 10.13346/j.mycosystema.2013.02.007.
	Tan JW, Liu W, Wang Z, et al. Reclassification of 33 clinical strains of Sporothrix from northern China based on phenotypic and molecular characters［J］. Mycosystema, 2013, 32（2）: 161⁃167. DOI: 10.13346/j.mycosystema.2013.02.007.
［9］	马振友, 张建中, 郑怀林. 中国皮肤科科学史［M］. 北京: 北京科学技术出版社, 2015: 411⁃415.
	Ma ZY, Zhang JZ, Zheng HL. The history of Chinese dermatology science［M］. Beijing: Beijing science and techology press,2015: 411⁃415.
［10］	金学洙, 李福秋, 朱明姬, 等. 从芦苇等植物及土壤中分离孢子丝菌的研究［J］. 中华皮肤科杂志, 1998, 31（5）: 298⁃299. DOI: 10.3760/j.issn.0412⁃4030.1998.05.009.
	Jin XZ, Li FQ, Zhu MJ, et al. Isolation of Sporothrix from Reed and Soil［J］. Chin J Dermatol, 1998, 31（5）: 298⁃299. DOI: 10.3760/j.issn.0412⁃4030.1998.05.009.
［11］	孙宝符. 吉林省芦苇产区及造纸厂孢子丝菌病流行病学报告［J］. 临床皮肤科杂志, 1988, 1: 32.
	Sun BF. Sporotrichosis in reed⁃producing regions and paper mills in Jilin province: an epidemiological study［J］. J Clin Dermatol, 1988, 1: 32.
［12］	李鹤玉, 宋军, 张岩, 等. 黑龙江省肇东地区孢子丝菌病流行病学调查［J］. 中华皮肤科杂志, 1995, 28（6）: 401⁃402.
	Li HY, Song J, Zhang Y, et al. Epidemiology of sporotrichosis in Zhaodong, Heilongjiang province［J］. Chin J Dermatol, 1995, 28（6）: 401⁃402.
［13］	Kauffman CA. Sporotrichosis［J］. Clin Infect Dis, 1999, 29（2）: 231⁃236; quiz 237. DOI: 10.1086/520190.
［14］	Ishizaki H, Kawasaki M, Aoki M, et al. Mitochondrial DNA analysis of Sporothrix schenckii in Costa Rica［J］. J Med Vet Mycol, 1996, 34（1）: 71⁃73.
［15］	Miller SD, Keeling JH. Ant sting sporotrichosis［J］. Cutis, 2002, 69（6）: 439⁃442.
［16］	雷奥先, 刘佩铭. 蜂蜇后继发面部孢子丝菌病一例［J］. 广西医学, 1993, 51（1）: 51⁃52.
	Lei AX, Liu PM. A case of sporotrichosis following bee sting［J］. Guangxi Med, 1993, 51（1）: 51⁃52.
［17］	Araujo TD, Marques CA, Kerdel F. Sporotrichosis. Int J Dermatol, 2001, 40（12）: 732⁃742. DOI: 10.1046/j.1365⁃4362.2001.01295.
［18］	Jacobson ES. Pathogenic roles for fungal melanins［J］. Clin Microbiol Rev, 2000, 13（4）: 708⁃717.
［19］	Romero⁃Martinez R, Wheeler M, Guerrero⁃Plata A, et al. Biosynthesis and functions of melanin in Sporothrix schenckii［J］. Infect Immun, 2000, 68（6）: 3696⁃3703.
［20］	Lima OC, Bouchara JP, Renier G, et al. Immunofluorescence and flow cytometry analysis of fibronectin and laminin binding to Sporothrix schenckii yeast cells and conidia［J］. Microb Pathog, 2004, 37（3）: 131⁃140. DOI: 10.1016/j.micpath.2004.06.005.
［21］	Scott EN, Muchmore HG, Fine DP. Activation of the alternative complement pathway by Sporothrix schenckii［J］. Infect Immun, 1986, 51（1）: 6⁃9.
［22］	Torinuki W, Tagami H. Complement activation by Sporothrix schenckii［J］. Arch Dermatol Res, 1985, 277（4）: 332⁃333.
［23］	Mahlberg MJ, Patel R, Rosenman K, et al. Fixed cutaneous sporotrichosis［J］. Dermatol Online J, 2009, 15（8）: 5.
［24］	Rocha MM, Dassin T, Lira R, et al. Sporotrichosis in patient with AIDS: report of a case and review［J］. Rev Iberoam Micol, 2001, 18（3）: 133⁃136.
［25］	唐书谦, 叶庆佾, 钟白玉, 等.孢子丝菌病组织切片病原体检测研究［J］. 临床皮肤科杂志, 1990, 19（3）: 129.
	Tang SQ, Ye QY, Zhong BY, et al. Detection of pathogens in Sporotrichosis tissue sections［J］. J clin Dermatol, 1990, 19（3）: 129.
［26］	Dominguez⁃Soto L, Hojyo⁃Tomoka MT. The intradermal sporo⁃trichin test and the diagnosis of sporotrichosis［J］. Int J Dermatol, 1983, 22（9）: 520.
［27］	Kauffman CA, Bustamante B, Chapman SW, et al. Clinical practice guidelines for the management of sporotrichosis: 2007 update by the Infectious Diseases Society of America［J］. Clin Infect Dis, 2007, 45（10）: 1255⁃1265. DOI: 10.1086/522765.
［28］	de Lima Barros MB, Schubach AO, de Vasconcellos Carvalhaes de Oliveira R, et al. Treatment of cutaneous sporotrichosis with itraconazole--study of 645 patients［J］. Clin Infect Dis, 2011, 52（12）:e200⁃206. DOI: 10.1093/cid/cir245.
［29］	Song Y, Zhong SX, Yao L, et al. Efficacy and safety of itraconazole pulses vs. continuous regimen in cutaneous sporotrichosis［J］. J Eur Acad Dermatol Venereol, 2011, 25（3）: 302⁃305. DOI: 10.1111/j.1468⁃3083.2010.03785.x.
［30］	Francesconi G, Francesconi dVAC, Passos SL, et al. Comparative study of 250 mg/day terbinafine and 100 mg/day itraconazole for the treatment of cutaneous sporotrichosis［J］. Mycopathologia, 2011, 171（5）:349⁃354. DOI: 10.1007/s11046⁃010⁃9380⁃8.
［31］	赵敬军, 张正华, 刘维达. 特比萘芬（兰美抒）在中国应用 6 年情况回顾［J］.临床皮肤科杂志, 2001, 30（4）: 272⁃275. DOI: 10.3969/j.issn.1000⁃4963.2001.04.040.
	Zhao JJ, Zhang ZH, Liu WD. Lamisil in China: review of six year experiences［J］. J clin Dermatol, 2001, 30（4）: 272⁃275. DOI: 10.3969/j.issn.1000⁃4963.2001.04.040.
［32］	Bonifaz A, Fierro L, Saúl A, et al. Cutaneous sporotrichosis. Intermittent treatment （pulses） with itraconazole［J］. Eur J Dermatol, 2008, 18（1）: 61⁃64. DOI: 10.1684/ejd.2008.0312.
［33］	Gilaberte Y, Aspiroz C, Alejandre MC, et al. Cutaneous sporo⁃trichosis treated with photodynamic therapy: an in vitro and in vivo study［J］. Photomed Laser Surg, 2014, 32（1）: 54⁃57. DOI: 10.1089/pho.2013.3590.
［34］	王爱平, 高那, 刘伟, 等.伊曲康唑联合特比萘芬治疗孢子丝菌病疗效及其对病原真菌体外抗菌活性研究［J］. 中国真菌学杂志, 2011, 6（1）: 5⁃9. DOI: 10.3969/j.issn.1673⁃3827.2011.01. 002.
	Wang AP, Gao N, Liu W, et al. Combination of itraconazole and terbinafine in treating sporotriehosls and their in vitro antifungal activities against Sporothrix schenckii［J］. Chin J Mycol, 2011, 6（1）: 5⁃9. DOI: 10.3969/j.issn.1673⁃3827.2011. 01.002.
［35］	吕雪莲, 刘晓明, 马洁浩, 等. 碘化钾与伊曲康唑联合治疗孢子丝菌病的实验研究［J］.中国皮肤性病学杂志, 2015, 19（12）: 719⁃721, 726. DOI: 10.3969/j.issn.1001⁃7089.2005.12.006.
	Lyu XL, Liu XM, Ma JH, et al. An experimental study on the combined therapy of potassium iodide and itraconazole in murine sporotrichosis［J］. Chin J Derm Venereol, 2015, 19（12）: 719⁃721, 726. DOI: 10.3969/j.issn.1001⁃7089. 2005.12.006.

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