婴幼儿血管瘤的局部药物治疗进展

摘要/Abstract

摘要：

目的婴幼儿血管瘤是婴幼儿最常见的良性软组织肿瘤。普萘洛尔治疗婴幼儿血管瘤的安全性和有效性均优于传统的糖皮质激素，但口服普萘洛尔可导致系统性并发症。局部应用β受体阻滞剂成为婴幼儿血管瘤治疗研究的新热点，如局部外用0.5%噻吗洛尔滴眼液、0.1%噻吗洛尔凝胶、普萘洛尔纳米水溶胶等。另外，局部外用5%咪喹莫特软膏、局部注射药物以及联合不同波长激光等均可作为婴幼儿血管瘤的治疗选择。本文简要综述婴幼儿血管瘤局部药物治疗方法。

Abstract:

Sun Caihong, Gu Heng Department of Dermatology, Affiliated People′s Hospital of Jiangsu University, Zhenjiang 212002, Jiangsu, China （Sun CH）; Hospital of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing 210042, China （Gu H） Corresponding author: Gu Heng, Email: guheng@aliyun.com 【Abstract】 Infantile hemangioma （IH） is the most common benign soft tissue tumor in infants. The safety and efficacy of propranolol are superior to those of traditional glucocorticoids for the treatment of IH, but oral propranolol can cause systemic complications. Recently, topical beta?blockers have become a new research hotspot in the treatment of IH, including 0.5% timolol ophthalmic solution, 0.1% timolol gel?forming solution, nano?propranolol?dispersed hydrogel, etc. In addition, topical 5% imiquimod ointment, local injections and combined lasers at different wavelengths all can be alternative therapies for IH. This review summarizes topical drug treatment of IH.

孙彩虹顾恒. 婴幼儿血管瘤的局部药物治疗进展[J]. 中华皮肤科杂志, 2016, 49(12): 903-906.

Caihong SUN. Topical drug treatment of infantile hemangioma[J]. Chinese Journal of Dermatology, 2016, 49(12): 903-906.

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