敏感性皮肤及其处理对策

摘要/Abstract

摘要：

敏感性皮肤是指皮肤对多种内外因素的耐受性降低、敏感性增强。敏感皮肤的发生与年龄、性别、身体解剖部位以及种族有关。敏感性皮肤者生活质量下降。由于其病因不明，有效控制敏感性皮肤一直是个挑战。近来研究显示，表皮通透屏障功能和瞬时感受器电位香草酸受体与敏感性皮肤的发生有关。因此，改善表皮通透屏障功能和瞬时感受器电位香草酸受体抑制剂可能有助于改善敏感性皮肤。

Abstract:

Man Maoqiang, Se Kyoo Jeong, Byeong Deog Park, Peter M Elias Department of Dermatology, San Francisco Veterans Affairs Medical Center, University of California San Francisco, School of Medicine, and Northern California Institute for Research and Education, San Francisco, CA 94121, USA （Man MQ, Elias PM）; Research Division, NeoPharm Co., Ltd., Daejeon, Korea （Jeong SK, Park BD） Corresponding author: Man Maoqiang, Email: mqman@hotmail.com 【Abstract】 Sensitive skin is a skin condition featured by high sensitivity and low tolerance in response to external and internal stimuli. The prevalence of sensitive skin varies with age, gender, body sites, as well as race. The quality of life is substantially reduced in subjects with sensitive skin. Due to uncertainty of etiology, it has been a challenge to effectively manage sensitive skin. Recent studies have demonstrated pathogenic roles of epidermal permeability barrier and transient receptor potential vanilloid 1 （TRPV1） in the development of sensitive skin. Therefore, improvement in epidermal permeability barrier function and utilization of TRPV1 inhibitors may be valuable approaches to the management of sensitive skin.

蔄茂强 Se Kyoo Jeong Byeong Deog Park Peter M Elias. 敏感性皮肤及其处理对策[J]. 中华皮肤科杂志, 2016, 49(12): 899-902.

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