Abstract:

Chen Lingling*, Chen Xiaojian, Shi Xin, Wu Jian, Cai Meihong, Wu Lei, Zhang Yun, Yang Xiaowen, Xu Qianqian, Su Yuhua. *Department of Dermatology, Suzhou Municipal Hospital, Suzhou 215006, China Corresponding authors: Shi Xin, Email: shx9@163.com; Su Yuhua, Email: su84088@163.com 【Abstract】 Objective To evaluate the influence of a leukotriene receptor antagonist, montelukast, on patch test reactions to routine screening series of allergens. Methods Forty-two patients with positive （++） patch test reactions to one or more allergens included in routine screening series were sequentially collected at the dermatology outpatient clinic. After the first patch test, all the patients were given oral montelukast 10 mg once daily for 14 consecutive days. The patch test was conducted again on day 11, and patch test results were evaluated on day 14. The degree of patch test reactions from "－" to "+++" was converted into numeric values from "0" to "4" respectively for statistical evaluation. The results were analyzed by Wilcoxon Matched-Pairs Signed-Ranks Test using the software SPSS17.0. Results Forty-one testees completed the study. Strongly positive （++） reactions were observed in 49 chambers （42 testees） during the first patch test, of which, 45 remained strongly positive （++）, 1 turned from "++" to "+", and 2 from "++" to "+++" during the second patch test. No significant difference was observed in total results between the two patch tests（Z = 0.82, P = 0.41）. Conclusion The inhibitory effect of montelukast on skin patch test reactions to routine screening series of allergens is limited.