关键词: 晒伤, 氟芬那酸丁酯, 临床试验

Abstract: Yang Suqing, An Yuepeng, Yan Jingdong. Department of Dermatology, First Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin 150040, China Corresponding author: Yan Jingdong, Email: yanjingdong189@163.com 【Abstract】 Objective To evaluate the efficacy and safety of butyl flufenamate ointment for the treatment of solar dermatitis. Methods Sixty-four patients with solar dermatitis were randomly divided into the observation group （n = 32） and control group （n = 32） to topically apply butyl flufenamate ointment and diclofenac sodium cream, respectively, for 3 weeks. The efficacy was evaluated by lesion scores and a visual analog scale for pruritus. Results At the end of the treatment, 4 patients in the observation group were clinically cured, 19 markedly improved, l7 improved, and 2 showed no improvement; meanwhile, 2 patients in the control group were clinically cured, 11 markedly improved, 14 improved, and 5 showed no improvement. The total response rate was significantly higher （93.8% vs. 84.4%, P < 0.05）, while the pruritus score was significantly lower （P < 0.05） in the observation group than in the control group. Conclusion Butyl flufenamate ointment is superior to dicofenac sodium cream in terms of both efficacy and anti-pruritic effect.

Key words: Sunburn, Butyl flufenamate, Clinical trials