中华皮肤科杂志 ›› 2014, Vol. 47 ›› Issue (6): 426-428.

• 研究报道 • 上一篇    下一篇

两种羟基乙酸治疗面部寻常痤疮的疗效观察

李咏1,鲜燕1,李利2   

  1. 1. 四川大学华西医院
    2. 成都市四川大学华西医院皮肤科
  • 收稿日期:2013-08-12 修回日期:2014-02-14 发布日期:2014-06-01
  • 通讯作者: 李利 E-mail:lilihx_scu@scu.edu.cn

Treatment of acne vulgaris with two glycolic acid-containing preparations: a clinical observation

  • Received:2013-08-12 Revised:2014-02-14 Published:2014-06-01

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摘要： 目的 评价两种羟基乙酸活肤液治疗面部痤疮的临床疗效和安全性。 方法 随机、单盲、自身半脸对照试验。60例轻中度痤疮患者，随机分配左右面部为试验侧或对照侧，依次应用浓度为20%、35%、50%、70%两种羟基乙酸活肤液治疗4次，第1次与第2次治疗间隔2周，以后每4周治疗1次。每次治疗前及最后1次治疗后4周计算两侧面部炎性和非炎性皮损数，并按照6级评分法分别观察痘印、毛孔粗大和痤疮瘢痕恢复情况。 结果 治疗2、6、10、14周后，试验侧炎性皮损改善率分别为20.4%、43.3%、66.9%、80.2%，对照侧分别为21.6%、44.2%、68.1%、79.8%；试验侧非炎性皮损改善率分别为18.5%、34.0%、41.3%、59.6%，对照侧分别为17.8%、31.2%、44.9%、57.1%。试验结束时，试验侧有效率为80.0%，对照侧有效率为78.3%。羟基乙酸治疗后均有不同程度的疼痛、红斑、白霜等不良反应，经冷敷等对症处理后症状缓解。两侧疗效和不良反应差异无统计学意义（P > 0.05）。 结论 两种羟基乙酸活肤液治疗面部痤疮均有效。

关键词: 痤疮，寻常, 羟基乙酸, 治疗结果

Abstract: Li Yong, Xian Yan, Li Li. Department of Dermatology, West China Hospital, Sichuan University, Chengdu 610041, China Corresponding author: Li Li, Email: lilihx_scu@scu.edu.cn 【Abstract】 Objective To evaluate the clinical efficacy and safety of two glycolic acid-containing liquid preparations for the treatment of facial acne vulgaris. Methods Sixty patients with mild to moderate acne vulgaris were included in a randomized, single-blinded, split-face, controlled study. The left and right sides of each patient′s face were randomly assigned to the test group （treated with one hydroxy acid-containing liquid preparation） and control group （treated with the other hydroxy acid-containing liquid preparation）. In total, all the patients were given four times of treatment at week 0, 2, 6 and 10 with the concentration of hydroxy acid in both preparations being 20%, 35%, 50% and 70%, respectively. The number of inflammatory and noninflammatory acne lesions was counted, and the improvement in acne mark, scar and pores was evaluated by a 6-point grading scale before every treatment and 4 weeks after the last treatment. Results At 2, 6, 10, and 14 weeks after initiation of treatment, the clearance rate for inflammatory lesions was 20.4%, 43.3%, 66.9% and 80.2% respectively in the test group, 21.6%, 44.2%, 68.1% and 79.8% respectively in the control group, while that for noninflammatory lesions was 18.5%, 34.0%, 41.3% and 59.6% respectively in the test group, 17.8%, 31.2%, 44.9% and 57.1% respectively in the control group. The response rate was 80.0% in the test group and 78.3% in the control group at the end of the study. Adverse effects were observed in both groups, including temporary pain, erythema and formation of hoar frost, all of which well responded to symptomatic treatment. There were no significant differences in clinical efficacy or adverse effects between the two groups （both P > 0.05）. Conclusion Both of the hydroxy acid-containing preparations are effective and safe for mild to moderate acne vulgaris.

Key words: Acne vulgaris, Glycolic acid, Treatment outcome

引用本文

李咏 鲜燕 李利. 两种羟基乙酸治疗面部寻常痤疮的疗效观察[J]. 中华皮肤科杂志, 2014,47(6):426-428. doi: