中华皮肤科杂志 ›› 2013, Vol. 46 ›› Issue (9): 671-673.

• 研究报道 • 上一篇    下一篇

透明质酸修护贴敷料对强脉冲光术后面部皮肤的修复作用

杨智1,涂颖2,尹锐3,杨慧兰4,王玮蓁5,李利6,林琳3,刘仲荣7,李咏8,王婷婷9,付俊10,王延婷11,徐薇10,庞勤12,杨成2,王刚13,何黎14   

  1. 1. 昆明医科大学第一附属医院
    2. 昆明医学院第一附属医院皮肤科
    3. 重庆第三军医大学西南医院皮肤科
    4. 广州军区总医院皮肤科
    5. 武汉市第一医院皮肤科
    6. 四川大学华西医院皮肤科
    7. 广州军区广州总医院皮肤科
    8. 四川大学华西医院
    9. 成都市四川大学华西医院皮肤科
    10. 西安 第四军医大学西京皮肤医院
    11. 西京医院
    12. 昆明医学院第一附属医院
    13. 第四军医大学西京医院皮肤科
    14. 昆明市昆明医学院第一附属医院皮肤科
  • 收稿日期:2013-01-14 修回日期:2013-03-29 出版日期:2013-09-15 发布日期:2013-09-01
  • 通讯作者: 何黎 E-mail:drheli2662@126.com
  • 基金资助:
    云南省汉族重度痤疮雄激素受体基因单倍型研究

Efficacy of a hyaluronic acid?鄄containing dressing for facial skin wound healing in patients with freckles after intensive pulsed light treatment

  • Received:2013-01-14 Revised:2013-03-29 Online:2013-09-15 Published:2013-09-01

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摘要： 【摘要】 目的 探讨透明质酸修护贴敷料对强脉冲光治疗后面部皮肤修复的安全性。方法 多中心、随机对照方法，对298例强脉冲光术后患者的面部皮肤外用透明质酸修护贴敷料或生理氯化钠溶液面膜，并对其中68例患者第3、7、14天进行皮肤生理功能测试，同时对所有患者的结痂脱落情况、患者对该产品的满意度及安全性进行评价。结果 治疗14 d后，在68例患者中，试验组角质层含水量为25.32 ± 4.14，经表皮水分丢失为14.08 ± 3.32，与治疗前及对照组比较，差异有统计学意义（P ＜ 0.01），皮肤油脂含量差异无统计学意义。所有患者中，试验组3 d内第1块结痂脱落患者例数和7 d内结痂完全脱落例数与对照组比较，差异均有统计学意义（χ２ = 7.774，P < 0.01；χ２ = 4.692，P < 0.05），两组患者对产品自评，差异均有统计学意义（P ＜ 0.05），观察期间均未出现不良反应。结论 透明质酸修护贴敷料对强脉冲光术后面部皮肤有辅助作用，有助于恢复皮肤屏障功能，安全性好。

关键词: 面部皮肤, 强脉冲光, 透明质酸

Abstract: YANG Zhi *, TU Ying, YIN Rui, YANG Hui-lan, WANG Wei-zhen, LI Li, LIN Lin, LIU Zhong-rong, LI Yong, WANG Ting-ting, FU Jun, WANG Yan-ting, XU Wei, PANG Qin, YANG Cheng, WANG Gang, HE Li. *Department of Dermatology, First Affiliated Hospital, Kunming Medical Univesity, Yunnan Provincial Institute of Dermatology and Venereology, Yunnan 650032, China Corresponding authors: HE Li, Email: heli2662@yahoo.com.cn; WANG Gang, Email: xjwgang@fmmu.edu.cn 【Abstract】 Objective To evaluate the safety of a hyaluronic acid-containing dressing for wound healing of facial skin in patients with freckles after intensive pulsed light （IPL） therapy． Methods A multicenter, randomized, open, controlled clinical trial was conducted. A total of 298 IPL-treated patients with freckles were recruited into this study. After IPL therapy, all the patients were randomly divided into two groups to be topically treated with a hyaluronic acid-containing dressing （experiment group） or a sodium chloride physiological solution-containing face mask （control group）. Skin physiological parameters, including sebum content, water content in stratum corneum, and transepidermal water loss, were invasively measured at the baseline, on day 3, 7 and 14 after the start of topical treatment. The formation and desquamation of irradiation-induced crusts were observed, the degree of patient satisfaction was evaluated, and adverse reactions were recorded. Results The water content in stratum corneum and transepidermal water loss were （25.32 ± 4.14） % and （14.08 ± 3.32） g?cm-2?h-1, respectively, in the experimental group on day 14, significantly different from those before treatment （both P<0.01） and those in the control group on day 14 （both P < 0.01）. Skin sebum content in the experiment group showed no significant changes during the 14-day treatment （P > 0.05）, and was similar to that in the control group on day 14 （P > 0.05）. The percentage of patients experiencing the initial desquamation of crusts within three days and that experiencing complete desquamation of crusts within seven days were significantly different between the experiment group and control group （χ２ = 7.774, P < 0.01; χ２ = 4.692, P < 0.05）. Statistical differences were observed in the degree of patient satisfaction between the two groups （P < 0.05）. No adverse reactions were reported during the trial. Conclusion The hyaluronic acid-containing dressing can restore skin barrier function with a good safety profile, and may serve as an adjuvant therapy for wound healing of facial skin after IPL irradiation．

Key words: Hyaluronic acid