中华皮肤科杂志 ›› 2013, Vol. 46 ›› Issue (10): 751-752.

• 研究报道 • 上一篇    下一篇

308单频准分子紫外光治疗无色素痣的临床疗效观察

马慧军1,宋联进2,杨扬1,胡蓉3,张明月1,高鹏飞1,王婧毅1   

  1. 1. 解放军第三o九医院皮肤科
    2. 北京309医院整形美容中心皮肤科
    3. 中国人民解放军第309医院
  • 收稿日期:2012-09-28 修回日期:2012-11-27 出版日期:2013-10-15 发布日期:2013-10-01
  • 通讯作者: 马慧军 E-mail:melanocytes@163.com
  • 基金资助:
    国家自然科学基金

Clinical observation on 308-nm monochromatic excimer light for the treatment of amelanotic nevus

  • Received:2012-09-28 Revised:2012-11-27 Online:2013-10-15 Published:2013-10-01
  • Contact: Hui-Jun Ma E-mail:melanocytes@163.com
  • Supported by:
    National Natural Science Foundation of China

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摘要： 目的 探讨308单频准分子紫外光对无色素痣的疗效及其不良反应。方法 308单频准分子紫外光对18例躯干部无色素痣的患者进行连续10次治疗，治疗前后检测皮损平均黑素值，随访3个月。结果 同初次治疗前基线值相比，治疗后皮损平均黑素值以次数依赖方式逐渐上升；约6次治疗后，皮损平均黑素值与周围正常皮肤平均黑素值百分率接近100%，随着随访时间的延长，皮损平均黑素值有下降趋势，约1个月后，皮损平均黑素值接近周围正常皮肤，3个月后皮损平均黑素值是正常皮肤的90%。治疗期间未发现水疱和瘢痕形成等不良反应。结论 308准分子紫外光治疗无色素痣安全有效，为稳定疗效可间隔3个月巩固治疗1次。

关键词: 准分子紫外光, 痣，色素

Abstract: MA Hui-jun, SONG Lian-jin, YANG Yang, HU Rong, ZHANG Ming-yue, GAO Peng-fei, WANG Jing-yi. Department of Dermatology, 309th Hospital of Chinese People′s Liberation Army, Beijing 100091, China Corresponding author: MA Hui-jun, Email: melanocytes@163.com 【Abstract】 Objective To evaluate the efficacy and safety of 308-nm monochromatic excimer light for the treatment of amelanotic nevus. Methods Eighteen patients with amelanotic nevus were treated with 308-nm monochromatic excimer light twice a week for five consecutive weeks. Melanin content index （MCI） was measured in the lesions before and after the treatment. After the final exposure, a three-month follow-up was carried out. Results After the start of treatment, the MCI in lesions increased in a session-dependent manner and approximated to 100% of that in perilesional normal skin after six sessions of treatment. The follow-up revealed a decrease trend in MCI after the end of the treatment, which was nearly equal to that in perilesional normal skin one month later, and dropped to about 90% of that three months later. No side effects such as blisters or scar were observed during the treatment. Conclusions The 308-nm monochromatic excimer light is safe and effective for the treatment of amelanotic nevus. Re-exposure to 308-nm monochromatic excimer light after three months is recommended as consolidation therapy.

Key words: Monochromatic excimer light