中华皮肤科杂志 ›› 2012, Vol. 45 ›› Issue (9): 673-674.

• 研究报道 • 上一篇    下一篇

白癜风患者血清巨噬细胞移动抑制因子和肿瘤坏死因子α的表达

肖汉龙1,陶娟2,刘辉峰3,安湘杰3,杨柳3,涂亚庭4   

  1. 1. 武警湖北省总队医院
    2.
    3. 华中科技大学同济医学院附属协和医院皮肤科
    4. 武汉华中科技大学同济医学院附属协和医院皮肤科
  • 收稿日期:2011-09-27 修回日期:2011-11-11 出版日期:2012-09-15 发布日期:2012-08-31
  • 通讯作者: 陶娟 E-mail:tjhappy@126.com
  • 基金资助:

    缺氧诱导因子纳米靶向治疗恶性黑色素瘤

etection of macrophage migration inhibition factor and tumor necrosis factor-α in the sera of patients with vitiligo

  • Received:2011-09-27 Revised:2011-11-11 Online:2012-09-15 Published:2012-08-31

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摘要：

目的 探讨白癜风患者血清中巨噬细胞移动抑制因子（MIF）和肿瘤坏死因子α（TNF-α）水平的变化及临床意义。方法 酶联免疫吸附试验和放射免疫法检测66例白癜风患者和30例健康对照血清MIF 和TNF-α的表达。结果 寻常型白癜风患者组和健康对照组血清MIF水平分别为（9.56 ± 1.65） μg/L和（5.18 ± 0.81） μg/L，TNF-α水平分别为（2.38 ± 0.37） μg/L和（1.78 ± 0.21） μg/L，寻常型白癜风患者组均显著高于健康对照组（P值均 ＜ 0.01）。寻常型白癜风患者血清MIF和TNF-α水平呈正相关（r = 0.89，P ＜ 0.05）。节段型白癜风患者组血清MIF和TNF-α水平与健康对照组比较，差异均无统计学意义（P > 0.05）。进展期白癜风患者血清MIF水平显著高于稳定期（P ＜ 0.01）。 结论 MIF和TNF-α可能在白癜风的发病机制中起一定作用。MIF与寻常型白癜风的活动性可能有关。

关键词: TNF-α

Abstract:

Objective To determine the serum levels of macrophage migration inhibition factor （MIF） and tumor necrosis factor-α （TNF-α） in patients with vitiligo, and to investigate their clinical significance. Methods The serum concentrations of MIF and TNF-α were determined by enzyme linked immunosorbent assay （ELISA） and radioimmunoassay respectively in 66 patients with vitiligo and 30 healthy controls. Results The patients with vitiligo vulgaris showed a significant higher serum level of MIF and TNF-α compared with the healthy controls （（9.56 ± 1.65） vs.（5.18 ± 0.81） μg/L, （2.38 ± 0.37） vs.（1.78 ± 0.21） μg/L, both P ＜ 0.01）. There was a positive correlation between the serum level of MIF and TNF-α（r = 0.89, P ＜ 0.05）. No statistical difference was observed in the serum levels of MIF or TNF-α between the healthy controls and patients with segmental vitiligo （both P > 0.05）. The serum level of MIF was significantly higher in patients with progressive vitiligo than in those with stable vitiligo （P ＜ 0.01）. Conclusions MIF and TNF-α might play a certain role in the pathogenesis of vitiligo, and MIF may be related to the activity of vitiligo vulgaris.

Key words: TNF-α

中图分类号: 

  • R758.69