中华皮肤科杂志 ›› 2012, Vol. 45 ›› Issue (4): 275-276.

• 研究报道 • 上一篇    下一篇

疫苗注射部位发生原发性皮肤间变性大细胞淋巴瘤一例

张春玲1,常建民2   

  1. 1. 北京医院皮肤科
    2. 卫生部北京医院
  • 收稿日期:2011-06-30 修回日期:2011-11-22 出版日期:2012-04-15 发布日期:2012-03-30
  • 通讯作者: 张春玲 E-mail:zcl5111@126.com

A case of primary cutaneous anaplastic large cell lymphoma at the vaccination site

Chun-Ling ZHANGjianmin chang2   

  • Received:2011-06-30 Revised:2011-11-22 Online:2012-04-15 Published:2012-03-30
  • Contact: Chun-Ling ZHANG E-mail:zcl5111@126.com

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摘要：

患者男，79岁，左上臂注射甲型流感疫苗后2个月，于注射部位出现红色结节，逐渐增大破溃。皮损组织病理检查：表皮内有淋巴细胞浸润，真皮内有大量密集淋巴细胞形成团块，细胞较大，胞质淡染，胞核有异形和核分裂。免疫组化染色：CD3、CD5和LCA阳性细胞各占90%，CD20和CD56均阴性，CD30阳性细胞占90%，CD10少量阳性，细胞角蛋白1-3、上皮膜抗原和突触囊泡蛋白阴性，间变性淋巴瘤激酶阴性，Ki-67阳性细胞为80%。诊断：注射甲型流感疫苗后注射局部原发性皮肤间变性大细胞淋巴瘤。

关键词: 原发性，皮肤，CD30阳性淋巴瘤

Abstract:

An unusual case of primary cutaneous anaplastic large cell lymphoma induced by influenza vaccination is reported. A 79-year-old man developed an erythematous nodule at the injection site on the upper left arm 2 months after vaccination against influenza A virus, which gradually grew and ulcerated. Pathological examination of the lesion revealed epidermal infiltrate of lymphocytes and numerous clumps of densely distributed lymphocytes with lightly stained cytoplasm, nuclear atypia and karyokinesis. Immunohistochemistry showed that the tumor cells stained positive for CD3 （90%）, CD5 （90%）, LCA （90%）, CD30 （90%）, CD10 （a few）, Ki-67 （80%）, but negative for CD20, CD56, cytokeratin 1-3, epithelial membrane antigen, synaptophysin, and anaplastic lymphoma kinase. The patient was diagnosed with primary cutaneous anaplastic large cell lymphoma at the injection site following vaccination against influenza A virus.

Key words: Primary,Cutaneous, CD30+lymphoma