中华皮肤科杂志 ›› 2012, Vol. 45 ›› Issue (3): 203-204.

• 研究报道 • 上一篇    下一篇

慢性荨麻疹患者食物过敏原特异性IgE及IgG检测

赵俊芳1,李桂珍2,赵宏丽3,李孟娟1   

  1. 1. 天津市长征医院
    2. 天津市中医药研究院附属医院
    3. 天津长征医院检验科
  • 收稿日期:2011-05-16 修回日期:2011-06-18 出版日期:2012-03-15 发布日期:2012-02-29
  • 通讯作者: 赵俊芳 E-mail:zjfnm@126.com

Detection of food allergen-specific IgE and IgG in patients with chronic urticaria

  • Received:2011-05-16 Revised:2011-06-18 Online:2012-03-15 Published:2012-02-29
  • Contact: ZHAO Jun-fang E-mail:zjfnm@126.com

PDF

38

赞

摘要：

目的 探讨慢性荨麻疹患者食物过敏原检测的意义。方法 对502例慢性荨麻疹患者进行食物过敏原特异性IgE与IgG检测，并进行统计学分析；同时对花生、黄豆、牛奶等过敏原的特异性IgE与IgG不同结果组进行双盲安慰剂食物激发试验。结果 １８８例患者食物过敏原特异性IgE阳性，阳性检出率为37.4%，其中腰果、花生黄豆阳性率较高；３６２例患者至少对１种食物过敏，IgG阳性检出率为72.1％，牛奶、鸡蛋、虾蟹为主要过敏原。双盲安慰剂食物激发试验证实，两种抗体检测都有假阳性与假阴性。结论 临床医生应在慢性荨麻疹的治疗中注意筛查食物过敏原，特别是IgG介导的过敏反应。

关键词: 特异性IgG

Abstract:

Objective To evaluate the roles of food allergen detection in patients with chronic urticaria. Methods Food allergen-specific IgE and IgG were detected in 502 patients with chronic urticaria and 100 normal human controls. Double-blind, placebo-controlled food challenge （DBPCFC） test was performed in patients who were proved to be positive or negative for food-specific IgG or IgE. Results Food-specific IgE was detected in 37.45％ （188/502） of the patients, with cashew, peanuts and soybeans as the most common allergens. The detection rate of food-specific IgG was 72.11％ （361/502）, with the major allergens being milk, egg, shrimp and crab. DBPCFC revealed false positivity and negativity in the detection of food-specific IgG and IgE. Conclusions Clinicians should pay attention to food allergen detection in the treatment of chronic urticaria, especially in the treatment of allergy mediated by IgG antibodies.

Key words: specific IgG