中华皮肤科杂志 ›› 2012, Vol. 45 ›› Issue (3): 199-200.

• 研究报道 • 上一篇    下一篇

白癜风患者焦虑状态与血清中血管紧张素Ⅱ水平的研究

纪晓丽1,臧运书2,汤占利1,葛红芬2,赵秀峰1   

  1. 1. 青岛大学医学院附属医院
    2. 青岛大学医学院附属医院皮肤科
  • 收稿日期:2011-03-28 修回日期:2011-12-07 出版日期:2012-03-15 发布日期:2012-02-29
  • 通讯作者: 汤占利 E-mail:tzldyx2010@sina.com

Anxiety state and serum angiontensinⅡ levels in patients with vitiligo

  • Received:2011-03-28 Revised:2011-12-07 Online:2012-03-15 Published:2012-02-29

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摘要：

目的 探讨白癜风患者焦虑情绪与血清中血管紧张素Ⅱ水平的关系。方法 选择60例进展期白癜风患者和健康体检者30例，采用焦虑自评量表 （SAS）对两组进行情绪评分，并比较分析两组之间及焦虑与无焦虑患者血清中血管紧张素Ⅱ水平。结果 白癜风患者组SAS评分（46.13 ± 11.72）明显高于正常对照组（36.73 ± 12.59），t = 3.50，P ＜ 0.01。白癜风患者焦虑情绪发生率为48.3%。女性患者SAS评分和焦虑发生率比男性患者显著增高（t = 2.47，χ2 = 4.58，P值均 ＜ 0.05）。未婚白癜风患者SAS评分和焦虑发生率比已婚患者显著增高（t = 2.59，P ＜ 0.01；χ2 = 6.17，P ＜ 0.05）。暴露部位白癜风患者SAS评分和焦虑发生率比非暴露部位患者显著增高（t = 3.60，P ＜ 0.01；χ2 = 5.84，P ＜ 0.05）。白癜风患者中具有焦虑情绪者血清中血管紧张素Ⅱ水平为（63.83 ± 10.92） ng/L，明显高于无焦虑情绪者（40.74 ± 8.70） ng/L，t =9.09，P < 0.01。结论 白癜风患者存在明显的焦虑情绪，且患者血清中血管紧张素Ⅱ水平与白癜风发病及焦虑状态关系密切，可能影响白癜风的发生与发展。

关键词: 血管紧张素Ⅱ

Abstract:

Objective To evaluate the possible correlation between anxiety state and serum angiontensinⅡ levels in patients with vitiligo. Methods Sixty patients with progressive vitiligo and 30 normal human controls were included in this study. Self-rating anxiety scale （SAS） was used to evaluate the anxiety state, and enzyme linked immunosorbent assay was performed to determine the serum level of angiontensinⅡ, in these subjects. Results SAS score was significantly increased in patients compared with the controls（46.13 ± 11.72 vs. 36.73 ± 12.59, t = 3.50, P ＜ 0.01）, and 48.3% of the patients were affected by anxiety. The SAS score and prevalence of anxiety were statistically higher in female than in male patients （t = 2.47, χ2 = 4.58, both P ＜ 0.05）, in unmarried than in married patients（t = 2.59, P ＜ 0.01; χ2 = 6.17, P ＜ 0.05）, in patients with lesions on exposed areas than in those with lesions on unexposed areas （t = 3.60, P ＜ 0.01; χ2 = 5.84, P ＜ 0.05）. In patients affected by anxiety, the level of serum angiontensinⅡwas significantly elevated compared with patients without anxiety （63.83 ± 10.92 vs. 40.74 ± 8.70 ng/L, t = 9.09, P < 0.01）. Conclusions Patients with vitiligo are usually affected by anxiety. The serum level of angiontensinⅡis closely correlated with anxiety state in patients with vitiligo as well as with the development of vitiligo, and may have an impact on the initiation and progression of vitiligo.

Key words: angiontensinⅡ